Rikkunshito and Ghrelin
Author
Source
International Journal of Peptides
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-01-26
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Rikkunshito is a popular Japanese traditional medicine that is prescribed in Japan to treat various gastrointestinal tract disorders.
In a double-blind controlled study, rikkunshito significantly ameliorated dysmotility-like dyspepsia and brought about a generalized improvement in upper gastric symptoms such as nausea and anorexia when compared with a control group.
Several studies in rats have shown enhanced gastric emptying and a protective effect on gastric mucosa injury with rikkunshito administration.
In addition, rikkunshito in combination with an anti-emetic drug is effective against anorexia and vomiting that occur as adverse reactions to chemotherapy in patients with advanced breast cancer.
However, the mechanism by which rikkunshito alleviates gastrointestinal disorders induced by anticancer agents remains unclear.
It has recently been shown that rikkunshito ameliorates cisplatin-induced anorexia by mediating an increase in the circulating ghrelin concentration.
Moreover, Fujitsuka et al.
found that decreased contractions of the antrum and duodenum in rats treated with a selective serotonin reuptake inhibitor were reversed by rikkunshito via enhancement of the circulating ghrelin concentration.
These findings show that rikkunshito may be useful for treatment of anorexia and may provide a new strategy for improvement of upper gastrointestinal dysfunction.
American Psychological Association (APA)
Hattori, Tomohisa. 2010. Rikkunshito and Ghrelin. International Journal of Peptides،Vol. 2010, no. 2010, pp.1-3.
https://search.emarefa.net/detail/BIM-460199
Modern Language Association (MLA)
Hattori, Tomohisa. Rikkunshito and Ghrelin. International Journal of Peptides No. 2010 (2010), pp.1-3.
https://search.emarefa.net/detail/BIM-460199
American Medical Association (AMA)
Hattori, Tomohisa. Rikkunshito and Ghrelin. International Journal of Peptides. 2010. Vol. 2010, no. 2010, pp.1-3.
https://search.emarefa.net/detail/BIM-460199
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460199