Spatiotemporal Dynamic Simulation of Acute PerfusionDiffusion Ischemic Stroke Lesions Evolution : A Pilot Study Derived from Longitudinal MR Patient Data
Joint Authors
Wardlaw, Joanna
Rekik, Islem
Durrleman, Stanley
Carpenter, Trevor
Allassonnière, Stéphanie
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The spatiotemporal evolution of stroke lesions, from acute injury to final tissue damage, is complex.
Diffusion-weighted (DWI) and perfusion-weighted (PWI) imaging is commonly used to detect early ischemic changes and attempts to distinguish between permanently damaged and salvageable tissues.
To date, 2D and 3D measures of diffusion/perfusion regions at individual timepoints have been widely used but may underestimate the true lesion spatio-temporal dynamics.
Currently there is no spatio-temporal 4D dynamic model that simulates the continuous evolution of ischemic stroke from MR images.
We determined whether a 4D current-based diffeomorphic model, developed in the field of statistical modeling for measuring the variability of anatomical surfaces, could estimate patient-specific spatio-temporal continuous evolution for MR PWI (measured as mean transit time, (MTT)) and DWI lesions.
In our representative pilot sample, the model fitted the data well.
Our dynamic analysis of lesion evolution showed different patterns; for example, some DWI/PWI dynamic changes corresponded with DWI lesion expansion into PWI lesions, but other patterns were much more complex and diverse.
There was wide variation in the time when the final tissue damage was reached after stroke for DWI and MTT.
American Psychological Association (APA)
Rekik, Islem& Allassonnière, Stéphanie& Durrleman, Stanley& Carpenter, Trevor& Wardlaw, Joanna. 2013. Spatiotemporal Dynamic Simulation of Acute PerfusionDiffusion Ischemic Stroke Lesions Evolution : A Pilot Study Derived from Longitudinal MR Patient Data. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-460202
Modern Language Association (MLA)
Rekik, Islem…[et al.]. Spatiotemporal Dynamic Simulation of Acute PerfusionDiffusion Ischemic Stroke Lesions Evolution : A Pilot Study Derived from Longitudinal MR Patient Data. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-460202
American Medical Association (AMA)
Rekik, Islem& Allassonnière, Stéphanie& Durrleman, Stanley& Carpenter, Trevor& Wardlaw, Joanna. Spatiotemporal Dynamic Simulation of Acute PerfusionDiffusion Ischemic Stroke Lesions Evolution : A Pilot Study Derived from Longitudinal MR Patient Data. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-460202
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460202