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Immunological Consequences of Antihelminthic Treatment in Preschool Children Exposed to Urogenital Schistosome Infection
Joint Authors
Cowan, Graeme J.
Rujeni, Nadine
Burchmore, Richard
Mutapi, Francisca
Taylor, David W.
Midzi, Nicholas
Nausch, Norman
Mduluza, Takafira
Cavanagh, David R.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-05
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Urogenital schistosomiasis, due to Schistosoma haematobium, is endemic in sub-Saharan Africa.
Control is by targeted treatment with praziquantel but preschool age children are excluded from control programs.
Immunological studies on the effect of treatment at this young age are scarce.
In light of studies in older individuals showing that praziquantel alters antischistosome immune responses and responses to bystander antigens, this study aims to investigate how these responses would be affected by treatment at this young age.
Antibody responses directed against schistosome antigens, Plasmodium falciparum crude and recombinant antigens, and the allergen house dust mite were measured in children aged 3 to 5 years before and 6 weeks after treatment.
The change in serological recognition of schistosome proteins was also investigated.
Treatment augmented antischistosome IgM and IgE responses.
The increase in IgE responses directed against adult worm antigens was accompanied by enhanced antigen recognition by sera from the children.
Antibody responses directed against Plasmodium antigens were not significantly affected by praziquantel treatment nor were levels of allergen specific responses.
Overall, praziquantel treatment enhanced, quantitatively and qualitatively, the antiworm responses associated with protective immunity but did not alter Plasmodium-specific responses or allergen-specific responses which mediate pathology in allergic disease.
American Psychological Association (APA)
Rujeni, Nadine& Nausch, Norman& Midzi, Nicholas& Cowan, Graeme J.& Burchmore, Richard& Cavanagh, David R.…[et al.]. 2013. Immunological Consequences of Antihelminthic Treatment in Preschool Children Exposed to Urogenital Schistosome Infection. Journal of Tropical Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-460207
Modern Language Association (MLA)
Rujeni, Nadine…[et al.]. Immunological Consequences of Antihelminthic Treatment in Preschool Children Exposed to Urogenital Schistosome Infection. Journal of Tropical Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-460207
American Medical Association (AMA)
Rujeni, Nadine& Nausch, Norman& Midzi, Nicholas& Cowan, Graeme J.& Burchmore, Richard& Cavanagh, David R.…[et al.]. Immunological Consequences of Antihelminthic Treatment in Preschool Children Exposed to Urogenital Schistosome Infection. Journal of Tropical Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-460207
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460207