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A Novel Porous Gelatin Composite Containing Naringin for Bone Repair
Joint Authors
Chen, Yueh-Sheng
Yao, Chun-Hsu
Lin, Kuen-Cherng
Chen, Kuo-Yu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
As Gu-Sui-Bu (GSB) is a commonly used Chinese medical herb for therapeutic treatment of bone-related diseases, naringin is its main active component.
This study elucidates how various concentrations of naringin solution affect the activities of bone cells, based on colorimetric, alkaline phosphatase activity, nodule formation, and tartrate-resistant acid phosphatase activity assays to determine the optimal concentration of naringin.
GGT composite was obtained by combining genipin cross-linked gelatin and β-tricalcium phosphate.
GGTN composite was prepared by mixing GGT composite with the predetermined concentration of naringin.
Porous GGT and GGTN composites were then made using a salt-leaching procedure.
The potential of the composites in repairing bone defects was evaluated and compared in vivo by using the biological response of rabbit calvarial bone to these composites.
Consequently, the most effective concentration of naringin was 10 mg/mL, which significantly enhanced the proliferation of osteoblasts, osteoclast activity, and nodule formation without affecting the alkaline phosphatase activity of osteoblasts and mitochondrial activity of mixed-bone cells.
Radiographic analysis revealed greater new bone ingrowth in the GGTN composite than in the GGT composite at the same implantation time.
Therefore, the GGTN composite is highly promising for use as a bone graft material.
American Psychological Association (APA)
Chen, Kuo-Yu& Lin, Kuen-Cherng& Chen, Yueh-Sheng& Yao, Chun-Hsu. 2013. A Novel Porous Gelatin Composite Containing Naringin for Bone Repair. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-460234
Modern Language Association (MLA)
Chen, Kuo-Yu…[et al.]. A Novel Porous Gelatin Composite Containing Naringin for Bone Repair. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-460234
American Medical Association (AMA)
Chen, Kuo-Yu& Lin, Kuen-Cherng& Chen, Yueh-Sheng& Yao, Chun-Hsu. A Novel Porous Gelatin Composite Containing Naringin for Bone Repair. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-460234
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460234