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Mycobacterium tuberculosis H37Rv : In Silico Drug Targets Identification by Metabolic Pathways Analysis
Joint Authors
Siddiqui, Mohd. Asif
Rana, Khyati
Arya, Arvind
Kapoor, Neelesh
Kumar, Hirdesh
Amir, Asad
Source
International Journal of Evolutionary Biology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Mycobacterium tuberculosis (Mtb) is a pathogenic bacteria species in the genus Mycobacterium and the causative agent of most cases of tuberculosis.
Tuberculosis (TB) is the leading cause of death in the world from a bacterial infectious disease.
This antibiotic resistance strain lead to development of the new antibiotics or drug molecules which can kill or suppress the growth of Mycobacterium tuberculosis.
We have performed an in silico comparative analysis of metabolic pathways of the host Homo sapiens and the pathogen Mycobacterium tuberculosis (H37Rv).
Novel efforts in developing drugs that target the intracellular metabolism of M.
tuberculosis often focus on metabolic pathways that are specific to M.
tuberculosis.
We have identified five unique pathways for Mycobacterium tuberculosis having a number of 60 enzymes, which are nonhomologous to Homo sapiens protein sequences, and among them there were 55 enzymes, which are nonhomologous to Homo sapiens protein sequences.
These enzymes were also found to be essential for survival of the Mycobacterium tuberculosis according to the DEG database.
Further, the functional analysis using Uniprot showed involvement of all the unique enzymes in the different cellular components.
American Psychological Association (APA)
Amir, Asad& Rana, Khyati& Arya, Arvind& Kapoor, Neelesh& Kumar, Hirdesh& Siddiqui, Mohd. Asif. 2014. Mycobacterium tuberculosis H37Rv : In Silico Drug Targets Identification by Metabolic Pathways Analysis. International Journal of Evolutionary Biology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-460256
Modern Language Association (MLA)
Amir, Asad…[et al.]. Mycobacterium tuberculosis H37Rv : In Silico Drug Targets Identification by Metabolic Pathways Analysis. International Journal of Evolutionary Biology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-460256
American Medical Association (AMA)
Amir, Asad& Rana, Khyati& Arya, Arvind& Kapoor, Neelesh& Kumar, Hirdesh& Siddiqui, Mohd. Asif. Mycobacterium tuberculosis H37Rv : In Silico Drug Targets Identification by Metabolic Pathways Analysis. International Journal of Evolutionary Biology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-460256
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460256