Interleukin-10 Inhibits Bone Resorption : A Potential Therapeutic Strategy in Periodontitis and Other Bone Loss Diseases
Joint Authors
Chen, Bin
Yang, Wenrong
Ma, Shouzhi
Guo, Jianbin
Zhang, Qian
Zhu, Xiaofeng
Yan, Fuhua
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Periodontitis and other bone loss diseases, decreasing bone volume and strength, have a significant impact on millions of people with the risk of tooth loss and bone fracture.
The integrity and strength of bone are maintained through the balance between bone resorption and bone formation by osteoclasts and osteoblasts, respectively, so the loss of bone results from the disruption of such balance due to increased resorption or/and decreased formation of bone.
The goal of therapies for diseases of bone loss is to reduce bone loss, improve bone formation, and then keep healthy bone density.
Current therapies have mostly relied on long-term medication, exercise, anti-inflammatory therapies, and changing of the life style.
However there are some limitations for some patients in the effective treatments for bone loss diseases because of the complexity of bone loss.
Interleukin-10 (IL-10) is a potent anti-inflammatory cytokine, and recent studies have indicated that IL-10 can contribute to the maintenance of bone mass through inhibition of osteoclastic bone resorption and regulation of osteoblastic bone formation.
This paper will provide a brief overview of the role of IL-10 in bone loss diseases and discuss the possibility of IL-10 adoption in therapy of bone loss diseases therapy.
American Psychological Association (APA)
Zhang, Qian& Chen, Bin& Yan, Fuhua& Guo, Jianbin& Zhu, Xiaofeng& Ma, Shouzhi…[et al.]. 2014. Interleukin-10 Inhibits Bone Resorption : A Potential Therapeutic Strategy in Periodontitis and Other Bone Loss Diseases. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-460318
Modern Language Association (MLA)
Zhang, Qian…[et al.]. Interleukin-10 Inhibits Bone Resorption : A Potential Therapeutic Strategy in Periodontitis and Other Bone Loss Diseases. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-460318
American Medical Association (AMA)
Zhang, Qian& Chen, Bin& Yan, Fuhua& Guo, Jianbin& Zhu, Xiaofeng& Ma, Shouzhi…[et al.]. Interleukin-10 Inhibits Bone Resorption : A Potential Therapeutic Strategy in Periodontitis and Other Bone Loss Diseases. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-460318
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460318