The Natural History of Uterine Leiomyomas : Morphometric Concordance with Concepts of Interstitial Ischemia and Inanosis
Joint Authors
Flake, Gordon P.
Robboy, Stanley J.
Dixon, Darlene
Kissling, Grace E.
Clayton, Natasha
Wicker, Benita
Flagler, Norris D.
Moore, Alicia B.
Source
Obstetrics and Gynecology International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Based upon our morphologic observations, we hypothesize and also provide morphometric evidence for the occurrence of progressive developmental changes in many uterine fibroids, which can be arbitrarily divided into 4 phases.
These developmental phases are related to the ongoing production of extracellular collagenous matrix, which eventually exceeds the degree of angiogenesis, resulting in the progressive separation of myocytes from their blood supply and a condition of interstitial ischemia.
The consequence of this process of slow ischemia with nutritional and oxygen deprivation is a progressive myocyte atrophy (or inanition), culminating in cell death, a process that we refer to as inanosis.
The studies presented here provide quantitative and semiquantitative evidence to support the concept of the declining proliferative activity as the collagenous matrix increases and the microvascular density decreases.
American Psychological Association (APA)
Flake, Gordon P.& Moore, Alicia B.& Flagler, Norris D.& Wicker, Benita& Clayton, Natasha& Kissling, Grace E.…[et al.]. 2013. The Natural History of Uterine Leiomyomas : Morphometric Concordance with Concepts of Interstitial Ischemia and Inanosis. Obstetrics and Gynecology International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-460340
Modern Language Association (MLA)
Flake, Gordon P.…[et al.]. The Natural History of Uterine Leiomyomas : Morphometric Concordance with Concepts of Interstitial Ischemia and Inanosis. Obstetrics and Gynecology International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-460340
American Medical Association (AMA)
Flake, Gordon P.& Moore, Alicia B.& Flagler, Norris D.& Wicker, Benita& Clayton, Natasha& Kissling, Grace E.…[et al.]. The Natural History of Uterine Leiomyomas : Morphometric Concordance with Concepts of Interstitial Ischemia and Inanosis. Obstetrics and Gynecology International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-460340
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460340