Traditional Medicinal Herbs and Food Plants Have the Potential to Inhibit Key Carbohydrate Hydrolyzing Enzymes In Vitro and Reduce Postprandial Blood Glucose Peaks In Vivo
Joint Authors
Mahmudi, M. Fawzi
Choudhary, M. Iqbal
Subratty, A. Hussein
Gurib-Fakim, A.
Nahar Khan, S.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
We hypothesized that some medicinal herbs and food plants commonly used in the management of diabetes can reduce glucose peaks by inhibiting key carbohydrate hydrolyzing enzymes.
To this effect, extracts of Antidesma madagascariense (AM), Erythroxylum macrocarpum (EM), Pittosporum senacia (PS), and Faujasiopsis flexuosa (FF), Momordica charantia (MC), and Ocimum tenuiflorum (OT) were evaluated for α-amylase and α-glucosidase inhibitory effects based on starch-iodine colour changes and PNP-G as substrate, respectively.
Only FF and AM extracts/fractions were found to inhibit α-amylase activity significantly (P<0.05) and coparable to the drug acarbose.
Amylase bioassay on isolated mouse plasma confirmed the inhibitory potential of AM and FF extracts with the ethyl acetate fraction of FF being more potent (P<0.05) than acarbose.
Extracts/fractions of AM and MC were found to inhibit significantly (P<0.05) α-glucosidase activity, with IC50 comparable to the drug 1-deoxynojirimycin.
In vivo studies on glycogen-loaded mice showed significant (P<0.05) depressive effect on elevation of postprandial blood glucose following ingestion of AM and MC extracts.
Our findings tend to provide a possible explanation for the hypoglycemic action of MC fruits and AM leaf extracts as alternative nutritional therapy in the management of diabetes.
American Psychological Association (APA)
Mahmudi, M. Fawzi& Subratty, A. Hussein& Gurib-Fakim, A.& Choudhary, M. Iqbal& Nahar Khan, S.. 2012. Traditional Medicinal Herbs and Food Plants Have the Potential to Inhibit Key Carbohydrate Hydrolyzing Enzymes In Vitro and Reduce Postprandial Blood Glucose Peaks In Vivo. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-460359
Modern Language Association (MLA)
Mahmudi, M. Fawzi…[et al.]. Traditional Medicinal Herbs and Food Plants Have the Potential to Inhibit Key Carbohydrate Hydrolyzing Enzymes In Vitro and Reduce Postprandial Blood Glucose Peaks In Vivo. The Scientific World Journal No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-460359
American Medical Association (AMA)
Mahmudi, M. Fawzi& Subratty, A. Hussein& Gurib-Fakim, A.& Choudhary, M. Iqbal& Nahar Khan, S.. Traditional Medicinal Herbs and Food Plants Have the Potential to Inhibit Key Carbohydrate Hydrolyzing Enzymes In Vitro and Reduce Postprandial Blood Glucose Peaks In Vivo. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-460359
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460359