Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract
Joint Authors
Kamalakkannan, Soundararajan
Akbarsha, Mohammad A.
Rajendran, Ramaswamy
Venkatesh, Ramasamy V.
Clayton, Paul
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
There is evidence that the principles present in the widely consumed Indian food plant C.
fimbriata extract (CFE) suppress appetite, and provide antiobesogenic and metabolic benefits.
The Diet-Induced Obesity (DIO) rat model was used to investigate CFE's anorexigenic effects.
Rats were randomly divided into three groups: (i) untreated control (C), (ii) control for cafeteria diet (CA), and (iii) cafeteria diet fed + CFE treated.
Rats in the test group received cafeteria diet and CFE from day one onwards.
CFE was administered by gavage at three doses (25, 50, 100 mg/Kg BW per day) for 90 days.
The antiobesogenic effects of CFE were evaluated by monitoring changes in feed intake, body weight, serum lipid and hormonal (leptin) profiles, fat pads, and liver weight.
Antiatherosclerotic effects were measured by histology.
CFE induced significant and dose-dependent inhibition of food intake, with dose-related prevention of gains in body weight, liver weight, and fat pad mass.
Alterations in serum lipid profiles associated with weight gain were similarly inhibited, as were the typical increases in serum leptin levels.
These data substantiate CFE's reported anorexigenic effects.
CFE treatment also conferred protection against atherogenesis.
We conclude that CFE possesses antiobesogenic and antiatherosclerotic properties.
American Psychological Association (APA)
Kamalakkannan, Soundararajan& Rajendran, Ramaswamy& Venkatesh, Ramasamy V.& Clayton, Paul& Akbarsha, Mohammad A.. 2010. Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract. Journal of Nutrition and Metabolism،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-460362
Modern Language Association (MLA)
Kamalakkannan, Soundararajan…[et al.]. Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract. Journal of Nutrition and Metabolism No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-460362
American Medical Association (AMA)
Kamalakkannan, Soundararajan& Rajendran, Ramaswamy& Venkatesh, Ramasamy V.& Clayton, Paul& Akbarsha, Mohammad A.. Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract. Journal of Nutrition and Metabolism. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-460362
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460362