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Differences in Protein Expression and Gene Amplification of Cyclins between Colon and Rectal Adenocarcinomas
Joint Authors
Aamodt, Rolf
Bukholm, Ida Rashida Khan
Bukholm, Geir
Andersen, Solveig Norheim
Bondi, Johan
Jonsdottir, Kristin
Source
Gastroenterology Research and Practice
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Adenocarcinomas of rectum and colon may be different with regard to the cellular biological basis for cancer development.
A material of 246 rectal cancers removed surgically at Akershus University Hospital in the years 1992–2000 was investigated and was compared to a material of 219 colon cancers operated on at Akershus University Hospital during the years 1988, 1990 and 1997–2000.
There were highly significant differences between the rectal and the colon cancers in the protein expression of cyclin D1, cyclin D3, cyclin E, nuclear β-catenin, and c-Myc and in gene amplification of cyclin A2, cyclin B1, cyclin D1, and cyclin E.
Gene amplification and protein expression in the rectal cancers correlated significantly for the cyclins B1, D3, and E.
A statistically significant relation was observed between overexpression of cyclin A2 and local relapse of rectal carcinomas, as higher expression of cyclin A2 was associated with lower local recurrence rate.
American Psychological Association (APA)
Aamodt, Rolf& Jonsdottir, Kristin& Andersen, Solveig Norheim& Bondi, Johan& Bukholm, Geir& Bukholm, Ida Rashida Khan. 2009. Differences in Protein Expression and Gene Amplification of Cyclins between Colon and Rectal Adenocarcinomas. Gastroenterology Research and Practice،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-460411
Modern Language Association (MLA)
Aamodt, Rolf…[et al.]. Differences in Protein Expression and Gene Amplification of Cyclins between Colon and Rectal Adenocarcinomas. Gastroenterology Research and Practice No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-460411
American Medical Association (AMA)
Aamodt, Rolf& Jonsdottir, Kristin& Andersen, Solveig Norheim& Bondi, Johan& Bukholm, Geir& Bukholm, Ida Rashida Khan. Differences in Protein Expression and Gene Amplification of Cyclins between Colon and Rectal Adenocarcinomas. Gastroenterology Research and Practice. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-460411
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460411