Cytotoxic T lymphocyte-Associated Antigen +49G Variant Confers Risk for Anti-CCP- and Rheumatoid Factor-Positive Type of Rheumatoid Arthritis Only in Combination with CT60∗G Allele
Joint Authors
Kisfali, Peter
Melegh, Bela
Magyari, Lili
Farago, Bernadett
Polgar, Noemi
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-08-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Controversial observations have been published on the association of the cytotoxic T lymphocyte associated antigen gene's variants with rheumatoid arthritis (RA).
After genotyping 428 patients and 230 matched controls, the prevalence of the CT60∗G allele was more frequent in RF- and/or anti-CCP-seropositive RApatients, compared to the healthy controls (P<.001).
Regression analysis revealed that the CT60∗G allele is a possible predisposing factor for RA in these subgroups.
No accumulation of the +49∗G allele was found among patients, and this variant was not found to correlate with RA.
Assaying the possible genotype variations, the +49∗G-CT60∗G allelic combination was accumulated in seropositive RA-subtypes, and was associated with the risk of RA (OR=1.73, P=.001 for the whole RA-population).
Although the +49∗G allele did not mean a predisposition to RA alone, in combination with CT60∗G it, also conferred risk, suggesting that the +49A/G variant is associated with the risk of RA only in certain haplotypes.
American Psychological Association (APA)
Farago, Bernadett& Kisfali, Peter& Magyari, Lili& Polgar, Noemi& Melegh, Bela. 2009. Cytotoxic T lymphocyte-Associated Antigen +49G Variant Confers Risk for Anti-CCP- and Rheumatoid Factor-Positive Type of Rheumatoid Arthritis Only in Combination with CT60∗G Allele. Autoimmune Diseases،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-460431
Modern Language Association (MLA)
Farago, Bernadett…[et al.]. Cytotoxic T lymphocyte-Associated Antigen +49G Variant Confers Risk for Anti-CCP- and Rheumatoid Factor-Positive Type of Rheumatoid Arthritis Only in Combination with CT60∗G Allele. Autoimmune Diseases No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-460431
American Medical Association (AMA)
Farago, Bernadett& Kisfali, Peter& Magyari, Lili& Polgar, Noemi& Melegh, Bela. Cytotoxic T lymphocyte-Associated Antigen +49G Variant Confers Risk for Anti-CCP- and Rheumatoid Factor-Positive Type of Rheumatoid Arthritis Only in Combination with CT60∗G Allele. Autoimmune Diseases. 2009. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-460431
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460431