Antigen-Based Immune Therapeutics for Type 1 Diabetes : Magic Bullets or Ordinary Blanks?
Joint Authors
Mallone, Roberto
Culina, Slobodan
Boitard, Christian
Source
Clinical and Developmental Immunology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-14
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The ideal drug of modern medicine is the one that achieves its therapeutic target with minimal adverse effects.
Immune therapy of Type 1 diabetes (T1D) is no exception, and knowledge of the antigens targeted by pathogenic T cells offers a unique opportunity towards this goal.
Different antigen formulations are being considered, such as proteins or peptides, either in their native form or modified ad hoc, DNA plasmids, and cell-based agents.
Translation from mouse to human should take into account important differences, particularly in the time scale of autoimmune progression, and intervention.
Critical parameters such as administration route, dosing and interval remain largely empirical and need to be further dissected.
T1D staging through immune surrogate markers before and after treatment will be key in understanding therapeutic actions and to finally turn ordinary blanks into magic bullets.
American Psychological Association (APA)
Culina, Slobodan& Boitard, Christian& Mallone, Roberto. 2011. Antigen-Based Immune Therapeutics for Type 1 Diabetes : Magic Bullets or Ordinary Blanks?. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-460459
Modern Language Association (MLA)
Culina, Slobodan…[et al.]. Antigen-Based Immune Therapeutics for Type 1 Diabetes : Magic Bullets or Ordinary Blanks?. Clinical and Developmental Immunology No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-460459
American Medical Association (AMA)
Culina, Slobodan& Boitard, Christian& Mallone, Roberto. Antigen-Based Immune Therapeutics for Type 1 Diabetes : Magic Bullets or Ordinary Blanks?. Clinical and Developmental Immunology. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-460459
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460459