The Role of NF-κB in PPARα-Mediated Hepatocarcinogenesis
Joint Authors
Nilakantan, Vani
Tharappel, Job
Li, Yixin
Calfee-Mason, Karen
Glauert, Howard P.
Twaroski, Michelle L.
Spear, Brett T.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-01-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
In this review, the role of NF-κB in the induction of hepatocarcinogenesis by peroxisome proliferators is examined.
The administration of peroxisome proliferators for more than a three-day period leads to the activation of NF-κB in the livers of rats and mice.
On the other hand, peroxisome proliferator activated receptor-α (PPARα) activation in non-hepatic tissues can lead to the inhibition of NF-κB activation.
Several lines of evidence support the hypothesis that the activation of NF-κB by peroxisome proliferators in the liver is mediated by oxidative stress.
The role of NF-κB in peroxisome proliferator-induced hepatocarcinogenesis has been examined using NF-κB knockout models.
Specifically, the induction of cell proliferation and the promotion of liver carcinogenesis are inhibited in mice lacking the p50 subunit of NF-κB.
Overall, the activation of NF-κB appears to be important in the carcinogenic activity of peroxisome proliferators.
American Psychological Association (APA)
Glauert, Howard P.& Calfee-Mason, Karen& Li, Yixin& Nilakantan, Vani& Twaroski, Michelle L.& Tharappel, Job…[et al.]. 2009. The Role of NF-κB in PPARα-Mediated Hepatocarcinogenesis. PPAR Research،Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-460460
Modern Language Association (MLA)
Glauert, Howard P.…[et al.]. The Role of NF-κB in PPARα-Mediated Hepatocarcinogenesis. PPAR Research No. 2008 (2008), pp.1-9.
https://search.emarefa.net/detail/BIM-460460
American Medical Association (AMA)
Glauert, Howard P.& Calfee-Mason, Karen& Li, Yixin& Nilakantan, Vani& Twaroski, Michelle L.& Tharappel, Job…[et al.]. The Role of NF-κB in PPARα-Mediated Hepatocarcinogenesis. PPAR Research. 2009. Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-460460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460460