The Role of NF-κB in PPARα-Mediated Hepatocarcinogenesis

Abstract EN

In this review, the role of NF-κB in the induction of hepatocarcinogenesis by peroxisome proliferators is examined.

The administration of peroxisome proliferators for more than a three-day period leads to the activation of NF-κB in the livers of rats and mice.

On the other hand, peroxisome proliferator activated receptor-α (PPARα) activation in non-hepatic tissues can lead to the inhibition of NF-κB activation.

Several lines of evidence support the hypothesis that the activation of NF-κB by peroxisome proliferators in the liver is mediated by oxidative stress.

The role of NF-κB in peroxisome proliferator-induced hepatocarcinogenesis has been examined using NF-κB knockout models.

Specifically, the induction of cell proliferation and the promotion of liver carcinogenesis are inhibited in mice lacking the p50 subunit of NF-κB.

Overall, the activation of NF-κB appears to be important in the carcinogenic activity of peroxisome proliferators.