The Influence of Prior Obstetrical History on Current 17-Hydroxyprogesterone Caproate Use

Abstract EN

Objective.

To determine if gestational age of prior preterm delivery influences a woman's receipt of 17-hydroxyprogesterone caproate (17-OHP-C).

Methods.

Retrospective cohort of women eligible for 17-OHP-C at Duke Obstetrics Clinic were identified by medical record review.

Sociodemographic and clinical characteristics were abstracted.

Results.

Of 104 eligible subjects, 82 (78.8%) were offered 17-OHP-C.

Of these, thirty-four (41.5%) declined.

The median gestational age of the most recent preterm delivery was significantly lower among subjects who accepted 17-OHP-C as compared to those who declined (28.7 vs.

34.0 weeks, P=.02) and in subjects offered 17-OHP-C compared to those not offered 17-OHP-C (30.2 vs.

36.0 weeks, P=.03).

Subjects not offered 17-OHP-C were more likely to have had an interval term delivery (31.8% vs.

9.7%, P=.009) Conclusion.

Women with earlier preterm deliveries were more likely to be offered and accept 17-OHP-C.

Prior obstetric history may influence both providers' and patients' willingness to discuss and/or accept 17-OHP-C.