Association between Depression and C-Reactive Protein
Joint Authors
Chiriboga, David E.
Rosal, Milagros C.
Whited, Matthew C.
Ma, Yunsheng
Merriam, Philip A.
Pagoto, Sherry L.
Li, Wenjun
Ockene, Ira S.
Hébert, James R.
Source
Cardiology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Depression has been associated with increased cardiovascular disease risk, and a depression-related elevation of high sensitivity C-reactive protein (hs-CRP) has been proposed as a possible mechanism.
The objective of this paper is to examine association between depression and high sensitivity C-reactive protein (hs-CRP).
Methods.
Subjects consisted of 508 healthy adults (mean age 48.5 years; 49% women, 88% white) residing in central Massachusetts.
Data were collected at baseline and at quarterly intervals over a one-year period per individual.
Multivariable linear mixed models were used to assess the association for the entire sample and by gender.
Results.
The mean Beck Depression Inventory score was 5.8 (standard deviation (SD) 5.4; median 4.3), and average serum hs-CRP was 1.8 mg/L (SD 1.7; median 1.2).
Results from the multivariable linear mixed models show that individuals with higher depression scores have higher levels of hs-CRP.
Analyses by gender show persistence of an independent association among women, but not among men.
Body mass index (BMI = weight(kg)/height(m)2) appears to be a partial mediator of this relationship.
Conclusion.
Depression score was correlated to hs-CRP levels in women.
Further studies are required to elucidate the biological mechanisms underlying these associations and their implications.
American Psychological Association (APA)
Ma, Yunsheng& Chiriboga, David E.& Pagoto, Sherry L.& Rosal, Milagros C.& Li, Wenjun& Merriam, Philip A.…[et al.]. 2010. Association between Depression and C-Reactive Protein. Cardiology Research and Practice،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-460483
Modern Language Association (MLA)
Ma, Yunsheng…[et al.]. Association between Depression and C-Reactive Protein. Cardiology Research and Practice No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-460483
American Medical Association (AMA)
Ma, Yunsheng& Chiriboga, David E.& Pagoto, Sherry L.& Rosal, Milagros C.& Li, Wenjun& Merriam, Philip A.…[et al.]. Association between Depression and C-Reactive Protein. Cardiology Research and Practice. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-460483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460483