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Genomic Structure and Variation of Nuclear Factor (Erythroid-Derived 2)-Like 2
Author
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-24, 24 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-10
Country of Publication
Egypt
No. of Pages
24
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
High-density mapping of mammalian genomes has enabled a wide range of genetic investigations including the mapping of polygenic traits, determination of quantitative trait loci, and phylogenetic comparison.
Genome sequencing analysis of inbred mouse strains has identified high-density single nucleotide polymorphisms (SNPs) for investigation of complex traits, which has become a useful tool for biomedical research of human disease to alleviate ethical and practical problems of experimentation in humans.
Nuclear factor (erythroid-derived 2)-like 2 (NRF2) encodes a key host defense transcription factor.
This review describes genetic characteristics of human NRF2 and its homologs in other vertebrate species.
NRF2 is evolutionally conserved and shares sequence homology among species.
Compilation of publically available SNPs and other genetic mutations shows that human NRF2 is highly polymorphic with a mutagenic frequency of 1 per every 72 bp.
Functional at-risk alleles and haplotypes have been demonstrated in various human disorders.
In addition, other pathogenic alterations including somatic mutations and misregulated epigenetic processes in NRF2 have led to oncogenic cell survival.
Comprehensive information from the current review addresses association of NRF2 variation and disease phenotypes and supports the new insights into therapeutic strategies.
American Psychological Association (APA)
Cho, Hye-Youn. 2013. Genomic Structure and Variation of Nuclear Factor (Erythroid-Derived 2)-Like 2. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-24.
https://search.emarefa.net/detail/BIM-460484
Modern Language Association (MLA)
Cho, Hye-Youn. Genomic Structure and Variation of Nuclear Factor (Erythroid-Derived 2)-Like 2. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-24.
https://search.emarefa.net/detail/BIM-460484
American Medical Association (AMA)
Cho, Hye-Youn. Genomic Structure and Variation of Nuclear Factor (Erythroid-Derived 2)-Like 2. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-24.
https://search.emarefa.net/detail/BIM-460484
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460484