Rosiglitazone and Fenofibrate Additive Effects on Lipids

Joint Authors

Castillo-Rojas, Luadino M.
Slim, Ahmad M.
Villines, Todd C.
Pearce Moore, Dorette
Slim, Jennifer N.
Hulten, Eddie

Source

Cholesterol

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-11-24

Country of Publication

Egypt

No. of Pages

4

Main Subjects

Biology

Abstract EN

Background.

To evaluate the effect of rosiglitazone, fenofibrate, or their combined use on plasma lipids in normoglycemic healthy adults.

Methods and Results.

Subjects were randomized in a double-blind fashion to rosiglitazone + placebo, fenofibrate + placebo, rosiglitazone + fenofibrate, or matching double placebo.

The between-group difference in the change in fasting TG, high-density lipoprotein cholesterol (HDL-C), LDL-C, and plasma apolipoproteins A-I, A-II, and C-III level were compared after 12 weeks of treatment.

A total of 548 subjects were screened and 41 met the inclusion criteria.

After 12 weeks of therapy, the median change in the triglyceride levels showed a significant reduction ranging from 47 to 55 mg per deciliter in the fenofibrate only and rosiglitazone/fenofibrate groups compared with placebo (P=0.0496).

However, the rosiglitazone only group did not show significant change in triglyceride level.

The change in the Apo AII showed increase in all the treatment groups compared with placebo (P=0.009).

There was also significant change in the Apo CIII that showed reduction of its level in the fenofibrate only and rosiglitazone/fenofibrate groups (P=0.0003).

Conclusion.

Rosiglitazone does not appear to modulate hypertriglyceridemia in patients with elevated triglycerides independent of glucose metabolism.

American Psychological Association (APA)

Slim, Ahmad M.& Castillo-Rojas, Luadino M.& Hulten, Eddie& Slim, Jennifer N.& Pearce Moore, Dorette& Villines, Todd C.. 2011. Rosiglitazone and Fenofibrate Additive Effects on Lipids. Cholesterol،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-460508

Modern Language Association (MLA)

Slim, Ahmad M.…[et al.]. Rosiglitazone and Fenofibrate Additive Effects on Lipids. Cholesterol No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-460508

American Medical Association (AMA)

Slim, Ahmad M.& Castillo-Rojas, Luadino M.& Hulten, Eddie& Slim, Jennifer N.& Pearce Moore, Dorette& Villines, Todd C.. Rosiglitazone and Fenofibrate Additive Effects on Lipids. Cholesterol. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-460508

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-460508