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Resident Stem Cells and Renal Carcinoma
Joint Authors
Bussolati, Benedetta
Camussi, Giovanni
Brossa, Alessia
Source
International Journal of Nephrology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
According to the cancer stem cell hypothesis tumors are maintained by a cancer stem cell population which is able to initiate and maintain tumors.
Tumor-initiating stem cells display stem or progenitor cell properties such as self-renewal and capacity to re-establish tumors that recapitulate the tumor of origin.
In this paper, we discuss data relative to the presence of cancer stem cells in human renal carcinoma and their possible origin from normal resident stem cells.
The cancer stem cells identified in human renal carcinomas are not derived from the normal CD133+ progenitors of the kidney, but rather from a more undifferentiated population that retains a mesenchymal phenotype.
This population is able to self-renewal, clonogenicity, and in vivo tumor initiation.
Moreover, they retain pluripotent differentiation capability, as they can generate not only the epithelial component of the tumor, but also tumor endothelial cells.
This suggests that renal cancer stem cells may contribute to the intratumor vasculogenesis.
American Psychological Association (APA)
Bussolati, Benedetta& Brossa, Alessia& Camussi, Giovanni. 2011. Resident Stem Cells and Renal Carcinoma. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-460519
Modern Language Association (MLA)
Bussolati, Benedetta…[et al.]. Resident Stem Cells and Renal Carcinoma. International Journal of Nephrology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-460519
American Medical Association (AMA)
Bussolati, Benedetta& Brossa, Alessia& Camussi, Giovanni. Resident Stem Cells and Renal Carcinoma. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-460519
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460519