Milk Products Containing Bioactive Tripeptides Have an Antihypertensive Effect in Double Transgenic Rats (dTGR) Harbouring Human Renin and Human Angiotensinogen Genes
Joint Authors
Vapaatalo, Heikki
Pilvi, Taru
Korpela, Riitta
Kautiainen, Hannu
Cheng, Zhong Jian
Mervaala, Eero
Jauhiainen, Tiina
Müller, Dominik N.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Tripeptides isoleucyl-prolyl-proline (IPP) and valyl-prolyl-proline (VPP) act as ACE inhibitors in vitro.
Double transgenic rats (dTGR) harbouring human renin and human angiotensinogen genes develop malignant hypertension due to increased angiotensin II formation.
The present study was aimed to evaluate possible antihypertensive effect of IPP and VPP in this severe model.
Four-week-old dTGR were randomized in three groups to receive: (1) water (control), (2) fermented milk containing IPP and VPP, and (3) IPP and VPP dissolved in water for three weeks.
Fermented milk, but not peptides in water, attenuated the development of hypertension in dTGR by 19 mmHg versus the control group (P=.023).
In vitro vascular function tests showed that high concentrations of the peptides evinced ACE inhibitory properties.
In other hypertension related variables, no significant differences between the treatment groups were found.
In conclusion, fermented milk product containing IPP and VPP prevents development of malignant hypertension in an animal model.
American Psychological Association (APA)
Jauhiainen, Tiina& Pilvi, Taru& Cheng, Zhong Jian& Kautiainen, Hannu& Müller, Dominik N.& Vapaatalo, Heikki…[et al.]. 2009. Milk Products Containing Bioactive Tripeptides Have an Antihypertensive Effect in Double Transgenic Rats (dTGR) Harbouring Human Renin and Human Angiotensinogen Genes. Journal of Nutrition and Metabolism،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-460522
Modern Language Association (MLA)
Jauhiainen, Tiina…[et al.]. Milk Products Containing Bioactive Tripeptides Have an Antihypertensive Effect in Double Transgenic Rats (dTGR) Harbouring Human Renin and Human Angiotensinogen Genes. Journal of Nutrition and Metabolism No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-460522
American Medical Association (AMA)
Jauhiainen, Tiina& Pilvi, Taru& Cheng, Zhong Jian& Kautiainen, Hannu& Müller, Dominik N.& Vapaatalo, Heikki…[et al.]. Milk Products Containing Bioactive Tripeptides Have an Antihypertensive Effect in Double Transgenic Rats (dTGR) Harbouring Human Renin and Human Angiotensinogen Genes. Journal of Nutrition and Metabolism. 2009. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-460522
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460522