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Vitamin K2, a Naturally Occurring Menaquinone, Exerts Therapeutic Effects on Both Hormone-Dependent and Hormone-Independent Prostate Cancer Cells
Joint Authors
Dakshinamoorthy, Gajalakshmi
Shetty, Aditya V.
Munirathinam, Gnanasekar
Kajdacsy-Balla, André
Samykutty, Abhilash
Kalyanasundaram, Ramaswamy
Zheng, Guoxing
Bosland, Maarten C.
Chen, Aoshuang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-24
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
In recent years, several studies have shown that vitamin k2 (VK2) has anticancer activity in a variety of cancer cells.
The antitumor effects of VK2 in prostate cancer are currently not known.
In the present study, we sought to characterize the anticancer potential of VK2 in both androgen-dependent and -independent prostate cancer cells.
Our investigations show that VK2 is able to suppress viability of androgen-dependent and androgen-independent prostate cancer cells via caspase-3 and -8 dependent apoptosis.
We also show that VK2 treatment reduces androgen receptor expression and PSA secretion in androgen-dependent prostate cancer cells.
Our results also implicate VK2 as a potential anti-inflammatory agent, as several inflammatory genes are downregulated in prostate cancer cells following treatment with VK2.
Additionally, AKT and NF-kB levels in prostate cancer cells are reduced significantly when treated with VK2.
These findings correlated with the results of the Boyden chamber and angiogenesis assay, as VK2 treatment reduced cell migration and angiogenesis potential of prostate cancer cells.
Finally, in a nude mice model, VK2 administration resulted in significant inhibition of both androgen-dependent and androgen-independent tumor growth.
Overall, our results suggest that VK2 may be a potential therapeutic agent in the treatment of prostate cancer.
American Psychological Association (APA)
Samykutty, Abhilash& Shetty, Aditya V.& Dakshinamoorthy, Gajalakshmi& Kalyanasundaram, Ramaswamy& Zheng, Guoxing& Chen, Aoshuang…[et al.]. 2013. Vitamin K2, a Naturally Occurring Menaquinone, Exerts Therapeutic Effects on Both Hormone-Dependent and Hormone-Independent Prostate Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-460557
Modern Language Association (MLA)
Samykutty, Abhilash…[et al.]. Vitamin K2, a Naturally Occurring Menaquinone, Exerts Therapeutic Effects on Both Hormone-Dependent and Hormone-Independent Prostate Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-460557
American Medical Association (AMA)
Samykutty, Abhilash& Shetty, Aditya V.& Dakshinamoorthy, Gajalakshmi& Kalyanasundaram, Ramaswamy& Zheng, Guoxing& Chen, Aoshuang…[et al.]. Vitamin K2, a Naturally Occurring Menaquinone, Exerts Therapeutic Effects on Both Hormone-Dependent and Hormone-Independent Prostate Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-460557
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460557