Immunomodulatory Activity of Lactococcus lactis A17 from Taiwan Fermented Cabbage in OVA-Sensitized BALBc Mice
Joint Authors
Tsai, Ying-Chieh
Chiang, Yi-Chin
Mei, Nai-Wen
Chao, Shiou-Huei
Liu, Yu-Wen
Mei, Hui-Ching
Liu, Yen-Wenn
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
From fermented Taiwan foods, we have isolated numerous lactic acid bacteria (LAB) of plant origin and investigated their biological activities.
This study aimed to investigate the immunomodulatory effect and mechanism of Lactococcus lactis A17 (A17), isolated from Taiwan fermented cabbage, on ovalbumin (OVA)-sensitized mice.
Human peripheral blood mononuclear cells were used to verify immune responses of A17 by IFN-γ production.
Live (A17-A) and heat-killed A17 (A17-H) were orally administered to OVA-sensitized BALB/c mice to investigate their effects on immunoglobulin (Ig) and cytokine production.
The mRNA expression of Toll-like receptors (TLR) and nucleotide binding oligomerization domain (NOD)-like protein receptors in spleen cells was analyzed by real-time RT-PCR.
Both live and heat-killed A17 modulate OVA-induced allergic effects.
B-cell response was modulated by diminishing IgE production and raising OVA-specific IgG2a production, while T-cell response was modulated by increasing IFN-γ production and decreasing IL-4 production.
The mRNA expression of NOD-1, NOD-2, and TLR-4 was down-regulated by A17 as well.
This is the first report to describe a naïve Lactococcus lactis A17 strain as a promising candidate for prophylactic and therapeutic treatments of allergic diseases via oral administration.
Our results suggest the ameliorative effects of A17 may be caused by modulating NOD-1 NOD-2, and TLR-4 expression.
American Psychological Association (APA)
Mei, Hui-Ching& Liu, Yen-Wenn& Chiang, Yi-Chin& Chao, Shiou-Huei& Mei, Nai-Wen& Liu, Yu-Wen…[et al.]. 2013. Immunomodulatory Activity of Lactococcus lactis A17 from Taiwan Fermented Cabbage in OVA-Sensitized BALBc Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-460597
Modern Language Association (MLA)
Mei, Hui-Ching…[et al.]. Immunomodulatory Activity of Lactococcus lactis A17 from Taiwan Fermented Cabbage in OVA-Sensitized BALBc Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-460597
American Medical Association (AMA)
Mei, Hui-Ching& Liu, Yen-Wenn& Chiang, Yi-Chin& Chao, Shiou-Huei& Mei, Nai-Wen& Liu, Yu-Wen…[et al.]. Immunomodulatory Activity of Lactococcus lactis A17 from Taiwan Fermented Cabbage in OVA-Sensitized BALBc Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-460597
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460597