Anti-Hepatitis B Virus X Protein in Sera Is One of the Markers of Development of Liver Cirrhosis and Liver Cancer Mediated by HBV
Joint Authors
Zhang, Shuai
Zhang, Xuan
Zhang, Xue-Zhi
Wu, Lian-Ying
Zhang, Xiao-Dong
Shan, Chang-Liang
Li, Nan
Ye, Li-Hong
Qiu, Li-Yan
Zhang, Hang
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-09-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Hepatitis B virus X protein (HBx) plays a crucial role in the development of hepatocellular carcinoma (HCC).
However, the significance of circulating antibody to hepatitis B virus X antigen (anti-HBx) in sera remains unclear.
In the present study, we examined the titers of anti-HBx (IgG) in the sera from 173 patients with chronic hepatitis B (CHB), 106 liver cirrhosis (LC), and 61 HCC by enzyme-linked immunosorbent assay (ELISA), respectively.
Our data showed that the positive rates of anti-HBx were higher in sera of LC (40.6%) and HCC (34.4%) than those of CHB (10.4%), P<.05.
In all 40 patients with anti-HBx+ out of 340 patients, 39 (97.5%) were HBsAg/HBeAg/anti-HBc+ and 1 (2.5%) was anti-HBs+ (P<.01), suggesting that anti-HBx in sera is a marker of HBV replication rather than a protective antibody.
Thus, our findings reveal that circulating anti-HBx in sera is one of the markers of development of LC and HCC mediated by HBV.
American Psychological Association (APA)
Zhang, Hang& Wu, Lian-Ying& Zhang, Shuai& Qiu, Li-Yan& Li, Nan& Zhang, Xuan…[et al.]. 2009. Anti-Hepatitis B Virus X Protein in Sera Is One of the Markers of Development of Liver Cirrhosis and Liver Cancer Mediated by HBV. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-460623
Modern Language Association (MLA)
Zhang, Hang…[et al.]. Anti-Hepatitis B Virus X Protein in Sera Is One of the Markers of Development of Liver Cirrhosis and Liver Cancer Mediated by HBV. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-460623
American Medical Association (AMA)
Zhang, Hang& Wu, Lian-Ying& Zhang, Shuai& Qiu, Li-Yan& Li, Nan& Zhang, Xuan…[et al.]. Anti-Hepatitis B Virus X Protein in Sera Is One of the Markers of Development of Liver Cirrhosis and Liver Cancer Mediated by HBV. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-460623
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460623
