![](/images/graphics-bg.png)
Antimycobacterial Activities of Novel 5-(1H-1,2,3-Triazolyl)Methyl Oxazolidinones
Joint Authors
Udo, Edet Ekpenyong
Varghese, Reny
Phillips, Oludotun Adebayo
Source
Tuberculosis Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The antibacterial activities of a series of triazolyl oxazolidinones against Mycobacterium tuberculosis strain in vitro and in vivo in a mice model are presented.
Most active compounds were noncytotoxic against VERO cells with acceptable selectivity indexes (SI) as measures of compound tolerability.
Structure activity relationships (SARs) revealed that analogs with alkylcarbonyl (IC90: < 0.2 to 0.422 μg/mL) and arylcarbonyl (IC90: < 0.2 to 2.103 μg/mL) groups at the piperazine 4N-position-displayed potent antimycobacterium activities, comparable to the methanesulfonyl (IC90: < 0.2 μg/mL) analog, linezolid (IC90: < 0.2 μg/mL), and isoniazid (IC90: < 0.034 μg/mL).
The furanylcarbonyl derivative also displayed potent activity, while the arylsulfonyl analogs were inactive.
Of the triazolyl oxazolidinones, the morpholino (PH-27) derivative with medium bioavailability in plasma was most active in vivo, but relatively less efficacious than isoniazid.
American Psychological Association (APA)
Phillips, Oludotun Adebayo& Udo, Edet Ekpenyong& Varghese, Reny. 2012. Antimycobacterial Activities of Novel 5-(1H-1,2,3-Triazolyl)Methyl Oxazolidinones. Tuberculosis Research and Treatment،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-460629
Modern Language Association (MLA)
Phillips, Oludotun Adebayo…[et al.]. Antimycobacterial Activities of Novel 5-(1H-1,2,3-Triazolyl)Methyl Oxazolidinones. Tuberculosis Research and Treatment No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-460629
American Medical Association (AMA)
Phillips, Oludotun Adebayo& Udo, Edet Ekpenyong& Varghese, Reny. Antimycobacterial Activities of Novel 5-(1H-1,2,3-Triazolyl)Methyl Oxazolidinones. Tuberculosis Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-460629
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460629