The Roles of Mitogen-Activated Protein Kinase Pathways in TGF-β-Induced Epithelial-Mesenchymal Transition
Joint Authors
Sun, Yujing
Gui, Ting
Shimokado, Aiko
Muragaki, Yasuteru
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The mitogen-activated protein kinase (MAPK) pathway allows cells to interpret external signals and respond appropriately, especially during the epithelial-mesenchymal transition (EMT).
EMT is an important process during embryonic development, fibrosis, and tumor progression in which epithelial cells acquire mesenchymal, fibroblast-like properties and show reduced intercellular adhesion and increased motility.
TGF-β signaling is the first pathway to be described as an inducer of EMT, and its relationship with the Smad family is already well characterized.
Studies of four members of the MAPK family in different biological systems have shown that the MAPK and TGF-β signaling pathways interact with each other and have a synergistic effect on the secretion of additional growth factors and cytokines that in turn promote EMT.
In this paper, we present background on the regulation and function of MAPKs and their cascades, highlight the mechanisms of MAPK crosstalk with TGF-β signaling, and discuss the roles of MAPKs in EMT.
American Psychological Association (APA)
Gui, Ting& Sun, Yujing& Shimokado, Aiko& Muragaki, Yasuteru. 2012. The Roles of Mitogen-Activated Protein Kinase Pathways in TGF-β-Induced Epithelial-Mesenchymal Transition. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-460635
Modern Language Association (MLA)
Gui, Ting…[et al.]. The Roles of Mitogen-Activated Protein Kinase Pathways in TGF-β-Induced Epithelial-Mesenchymal Transition. Journal of Signal Transduction No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-460635
American Medical Association (AMA)
Gui, Ting& Sun, Yujing& Shimokado, Aiko& Muragaki, Yasuteru. The Roles of Mitogen-Activated Protein Kinase Pathways in TGF-β-Induced Epithelial-Mesenchymal Transition. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-460635
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460635