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Role of Protein Biomarkers in the Detection of High-Grade Disease in Cervical Cancer Screening Programs
Joint Authors
Depuydt, Christophe E.
Brown, Charlotte A.
Sahebali, Shaira
De Prins, Frans
Malinowski, Douglas P.
Bogers, Johnannes
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Since the Pap test was introduced in the 1940s, there has been an approximately 70% reduction in the incidence of squamous cell cervical cancers in many developed countries by the application of organized and opportunistic screening programs.
The efficacy of the Pap test, however, is hampered by high interobserver variability and high false-negative and false-positive rates.
The use of biomarkers has demonstrated the ability to overcome these issues, leading to improved positive predictive value of cervical screening results.
In addition, the introduction of HPV primary screening programs will necessitate the use of a follow-up test with high specificity to triage the high number of HPV-positive tests.
This paper will focus on protein biomarkers currently available for use in cervical cancer screening, which appear to improve the detection of women at greatest risk for developing cervical cancer, including Ki-67, p16INK4a, BD ProEx C, and Cytoactiv HPV L1.
American Psychological Association (APA)
Brown, Charlotte A.& Bogers, Johnannes& Sahebali, Shaira& Depuydt, Christophe E.& De Prins, Frans& Malinowski, Douglas P.. 2012. Role of Protein Biomarkers in the Detection of High-Grade Disease in Cervical Cancer Screening Programs. Journal of Oncology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-460642
Modern Language Association (MLA)
Brown, Charlotte A.…[et al.]. Role of Protein Biomarkers in the Detection of High-Grade Disease in Cervical Cancer Screening Programs. Journal of Oncology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-460642
American Medical Association (AMA)
Brown, Charlotte A.& Bogers, Johnannes& Sahebali, Shaira& Depuydt, Christophe E.& De Prins, Frans& Malinowski, Douglas P.. Role of Protein Biomarkers in the Detection of High-Grade Disease in Cervical Cancer Screening Programs. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-460642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460642