APOA2 Polymorphism in Relation to Obesity and Lipid Metabolism
Joint Authors
Zaki, Moushira Erfan
Abdel-Hamid, Mohamed
Amr, Khalda Sayed
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objectives.
This study aims to analysis the relationship between c.-492T>C polymorphism in APOA2 gene and the risk for obesity in a sample of Egyptian adolescents and investigates its effect on body fat distribution and lipid metabolism.
Material and Methods.
A descriptive, cross-sectional study was conducted on 303 adolescents.
They were 196 obese and 107 nonobese, aged 16–19 years old.
Variables examined included body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), systolic and diastolic blood pressure (BP), body fat percentage (BF%), abdominal visceral fat layer, and dietary intake.
Abdominal visceral fat thickness was determined by ultrasonography.
The polymorphism in the APOA2 c.-492T>C was analyzed by PCR amplification.
Results.
Genotype frequencies were in Hardy-Weinberg equilibrium.
The frequency of the mutant C allele was significantly higher in obese cases compared to nonobese.
After multivariate adjustment, waist, BF% and visceral adipose layer, food consumption, and HDL-C were significantly higher in homozygous allele CC carriers than TT+TC carriers.
Conclusions.
Homozygous individuals for the C allele had higher obesity risk than carriers of the T allele and had elevated levels of visceral adipose tissue and serum HDL-C.
Moreover, the study shows association between the APOA2 c.-492T>C polymorphism and food consumption.
American Psychological Association (APA)
Zaki, Moushira Erfan& Amr, Khalda Sayed& Abdel-Hamid, Mohamed. 2013. APOA2 Polymorphism in Relation to Obesity and Lipid Metabolism. Cholesterol،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-460667
Modern Language Association (MLA)
Zaki, Moushira Erfan…[et al.]. APOA2 Polymorphism in Relation to Obesity and Lipid Metabolism. Cholesterol No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-460667
American Medical Association (AMA)
Zaki, Moushira Erfan& Amr, Khalda Sayed& Abdel-Hamid, Mohamed. APOA2 Polymorphism in Relation to Obesity and Lipid Metabolism. Cholesterol. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-460667
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460667