Creating a Long-Term Diabetic Rabbit Model
Joint Authors
Chien, Sufan
Mo, Yiqun
Wang, Jianpu
Wan, Rong
Zhang, Qunwei
Sherwood, Leslie C.
Source
Experimental Diabetes Research
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study was to create a long-term rabbit model of diabetes mellitus for medical studies of up to one year or longer and to evaluate the effects of chronic hyperglycemia on damage of major organs.
A single dose of alloxan monohydrate (100 mg/kg) was given intravenously to 20 young New Zealand White rabbits.
Another 12 age-matched normal rabbits were used as controls.
Hyperglycemia developed within 48 hours after treatment with alloxan.
Insulin was given daily after diabetes developed.
All animals gained some body weight, but the gain was much less than the age-matched nondiabetic rabbits.
Hyperlipidemia, higher blood urea nitrogen and creatinine were found in the diabetic animals.
Histologically, the pancreas showed marked beta cell damage.
The kidneys showed significantly thickened afferent glomerular arterioles with narrowed lumens along with glomerular atrophy.
Lipid accumulation in the cytoplasm of hepatocytes appeared as vacuoles.
Full-thickness skin wound healing was delayed.
In summary, with careful management, alloxan-induced diabetic rabbits can be maintained for one year or longer in reasonably good health for diabetic studies.
American Psychological Association (APA)
Wang, Jianpu& Wan, Rong& Mo, Yiqun& Zhang, Qunwei& Sherwood, Leslie C.& Chien, Sufan. 2010. Creating a Long-Term Diabetic Rabbit Model. Experimental Diabetes Research،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-460679
Modern Language Association (MLA)
Wang, Jianpu…[et al.]. Creating a Long-Term Diabetic Rabbit Model. Experimental Diabetes Research No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-460679
American Medical Association (AMA)
Wang, Jianpu& Wan, Rong& Mo, Yiqun& Zhang, Qunwei& Sherwood, Leslie C.& Chien, Sufan. Creating a Long-Term Diabetic Rabbit Model. Experimental Diabetes Research. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-460679
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460679