Effect of Chronic Morphine Consumption on Synaptic Plasticity of Rat’s Hippocampus : A Transmission Electron Microscopy Study
Joint Authors
Heidari, Mohammad Hassan
Bahrami, Zohreh
Movafag, Abolfazle
Shahriari, Ali
Amini, Abdollah
Heidari, Reihane
Source
Neurology Research International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
It is well known that the synapses undergo some changes in the brain during the course of normal life and under certain pathological or experimental circumstances.
One of the main goals of numerous researchers has been to find the reasons for these structural changes.
In the present study, we investigated the effects of chronic morphine consumption on synaptic plasticity, postsynaptic density thickness, and synaptic curvatures of hippocampus CA1 area of rats.
So for reaching these goals, 24 N-Mary male rats were randomly divided into three groups, morphine (n=8), placebo (n=8), and control (n=8) groups.
In the morphine group, complex of morphine (0.1, 0.2, 0.3, and 0.4) mg/mL and in the placebo (sucrose) group complex of sucrose (% 0.3) were used for 21 days.
After the end of drug treatment the animals were scarified and perfused intracardinally and finally the CA1 hippocampal samples were taken for ultrastructural studies, and then the obtained data were analyzed by SPSS and one-way analysis of variance.
Our data indicated that synaptic numbers per nm3 change significantly in morphine group compared to the other two groups (placebo and control) (P<0.001) and also statistical analysis revealed a significant difference between groups in terms of thickness of postsynaptic density (P<0.001) and synaptic curvature (P<0.007).
It seems that morphine dependence in rats plays a main role in the ultrastructural changes of hippocampus.
American Psychological Association (APA)
Heidari, Mohammad Hassan& Amini, Abdollah& Bahrami, Zohreh& Shahriari, Ali& Movafag, Abolfazle& Heidari, Reihane. 2013. Effect of Chronic Morphine Consumption on Synaptic Plasticity of Rat’s Hippocampus : A Transmission Electron Microscopy Study. Neurology Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-460746
Modern Language Association (MLA)
Heidari, Mohammad Hassan…[et al.]. Effect of Chronic Morphine Consumption on Synaptic Plasticity of Rat’s Hippocampus : A Transmission Electron Microscopy Study. Neurology Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-460746
American Medical Association (AMA)
Heidari, Mohammad Hassan& Amini, Abdollah& Bahrami, Zohreh& Shahriari, Ali& Movafag, Abolfazle& Heidari, Reihane. Effect of Chronic Morphine Consumption on Synaptic Plasticity of Rat’s Hippocampus : A Transmission Electron Microscopy Study. Neurology Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-460746
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460746