Green Tea Epigallocatechin Gallate Exhibits Anticancer Effect in Human Pancreatic Carcinoma Cells via the Inhibition of Both Focal Adhesion Kinase and Insulin-Like Growth Factor-I Receptor
Joint Authors
Chi, Hoang Thanh
Ohdomari, Iwao
Vu, Hoang Anh
Sasaki, Kousuke
Beppu, Yuuichi
Xinh, Phan Thi
Watanabe, Toshiki
Hara, Yukihiko
Sato, Yuko
Yamamoto, Hideaki
Tanii, Takashi
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The exact molecular mechanism by which epigallocatechin gallate (EGCG) suppresses human pancreatic cancer cell proliferation is unclear.
We show here that EGCG-treated pancreatic cancer cells AsPC-1 and BxPC-3 decrease cell adhesion ability on micro-pattern dots, accompanied by dephosphorylations of both focal adhesion kinase (FAK) and insulin-like growth factor-1 receptor (IGF-1R) whereas retained the activations of mitogen-activated protein kinase and mammalian target of rapamycin.
The growth of AsPC-1 and BxPC-3 cells can be significantly suppressed by EGCG treatment alone in a dose-dependent manner.
At a dose of 100 μM which completely abolishes activations of FAK and IGF-1R, EGCG suppresses more than 50% of cell proliferation without evidence of apoptosis analyzed by PARP cleavage.
Finally, the MEK1/2 inhibitor U0126 enhances growth-suppressive effect of EGCG.
Our data suggests that blocking FAK and IGF-1R by EGCG could prove valuable for targeted therapy, which can be used in combination with other therapies, for pancreatic cancer.
American Psychological Association (APA)
Vu, Hoang Anh& Beppu, Yuuichi& Chi, Hoang Thanh& Sasaki, Kousuke& Yamamoto, Hideaki& Xinh, Phan Thi…[et al.]. 2011. Green Tea Epigallocatechin Gallate Exhibits Anticancer Effect in Human Pancreatic Carcinoma Cells via the Inhibition of Both Focal Adhesion Kinase and Insulin-Like Growth Factor-I Receptor. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-460759
Modern Language Association (MLA)
Vu, Hoang Anh…[et al.]. Green Tea Epigallocatechin Gallate Exhibits Anticancer Effect in Human Pancreatic Carcinoma Cells via the Inhibition of Both Focal Adhesion Kinase and Insulin-Like Growth Factor-I Receptor. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-460759
American Medical Association (AMA)
Vu, Hoang Anh& Beppu, Yuuichi& Chi, Hoang Thanh& Sasaki, Kousuke& Yamamoto, Hideaki& Xinh, Phan Thi…[et al.]. Green Tea Epigallocatechin Gallate Exhibits Anticancer Effect in Human Pancreatic Carcinoma Cells via the Inhibition of Both Focal Adhesion Kinase and Insulin-Like Growth Factor-I Receptor. Journal of Biomedicine and Biotechnology. 2011. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-460759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460759