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The Prorenin and (Pro)renin Receptor : New Players in the Brain Renin-Angiotensin System?
Joint Authors
Peng, Hua
Feng, Yumei
Seth, Dale M.
Li, Wencheng
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
It is well known that the brain renin-angiotensin (RAS) system plays an essential role in the development of hypertension, mainly through the modulation of autonomic activities and vasopressin release.
However, how the brain synthesizes angiotensin (Ang) II has been a debate for decades, largely due to the low renin activity.
This paper first describes the expression of the vasoconstrictive arm of RAS components in the brain as well as their physiological and pathophysiological significance.
It then focus on the (pro)renin receptor (PRR), a newly discovered component of the RAS which has a high level in the brain.
We review the role of prorenin and PRR in peripheral organs and emphasize the involvement of brain PRR in the pathogenesis of hypertension.
Some future perspectives in PRR research are heighted with respect to novel therapeutic target for the treatment of hypertension and other cardiovascular diseases.
American Psychological Association (APA)
Li, Wencheng& Peng, Hua& Seth, Dale M.& Feng, Yumei. 2012. The Prorenin and (Pro)renin Receptor : New Players in the Brain Renin-Angiotensin System?. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-460776
Modern Language Association (MLA)
Li, Wencheng…[et al.]. The Prorenin and (Pro)renin Receptor : New Players in the Brain Renin-Angiotensin System?. International Journal of Hypertension No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-460776
American Medical Association (AMA)
Li, Wencheng& Peng, Hua& Seth, Dale M.& Feng, Yumei. The Prorenin and (Pro)renin Receptor : New Players in the Brain Renin-Angiotensin System?. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-460776
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460776