Stimulators and Activators of Soluble Guanylate Cyclase : Review and Potential Therapeutic Indications
Joint Authors
Nossaman, Bobby
Kadowitz, Philip J.
Pankey, Edward
Source
Critical Care Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The heme-protein soluble guanylyl cyclase (sGC) is the intracellular receptor for nitric oxide (NO).
sGC is a heterodimeric enzyme with α and β subunits and contains a heme moiety essential for binding of NO and activation of the enzyme.
Stimulation of sGC mediates physiologic responses including smooth muscle relaxation, inhibition of inflammation, and thrombosis.
In pathophysiologic states, NO formation and bioavailability can be impaired by oxidative stress and that tolerance to NO donors develops with continuous use.
Two classes of compounds have been developed that can directly activate sGC and increase cGMP formation in pathophysiologic conditions when NO formation and bioavailability are impaired or when NO tolerance has developed.
In this report, we review current information on the pharmacology of heme-dependent stimulators and heme-independent activators of sGC in animal and in early clinical studies and the potential role these compounds may have in the management of cardiovascular disease.
American Psychological Association (APA)
Nossaman, Bobby& Pankey, Edward& Kadowitz, Philip J.. 2012. Stimulators and Activators of Soluble Guanylate Cyclase : Review and Potential Therapeutic Indications. Critical Care Research and Practice،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-460801
Modern Language Association (MLA)
Nossaman, Bobby…[et al.]. Stimulators and Activators of Soluble Guanylate Cyclase : Review and Potential Therapeutic Indications. Critical Care Research and Practice No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-460801
American Medical Association (AMA)
Nossaman, Bobby& Pankey, Edward& Kadowitz, Philip J.. Stimulators and Activators of Soluble Guanylate Cyclase : Review and Potential Therapeutic Indications. Critical Care Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-460801
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460801