Genetic Polymorphisms of ORAI1 and Chronic Kidney Disease in Taiwanese Population
Joint Authors
Hwang, Daw-Yang
Cheng, Shih-Ying
Kao, Chih-Chin
Hsu, Yu-Wen
Wu, Mai-Szu
Chang, Jer-Ming
Lu, Hui-Chen
Chien, Shu-Chen
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Taiwan has very high incidence and prevalence of chronic kidney disease (CKD), which easily progresses to end-stage renal disease (ESRD).
The association between inflammation and CKD has been explored in several studies.
ORAI1 functions as a pore-forming subunit of the store-operated calcium channels which are involved in the regulation of immune system.
Hence, we conducted a case-control study to determine whether the genetic polymorphisms of ORAI1 gene is a susceptibility factor to CKD and its clinical features in a Taiwanese population.
Five hundred seventy-nine CKD patients from a hospital-based CKD care program were included in the study.
Five tagging single nucleotide polymorphisms (tSNPs) of ORAI1 were selected from the genotyping data of the Han Chinese population from the HapMap project.
Among these polymorphisms, rs12313273 was found to be significantly associated with elevated serum calcium levels, which has been linked to increased risk of death in CKD patients.
To have a better management of serum calcium, we suggest that ORAI1 polymorphisms might be used as a potential biomarker for initiating non-calcium-based phosphate binder in CKD patients in the future.
American Psychological Association (APA)
Hwang, Daw-Yang& Chien, Shu-Chen& Hsu, Yu-Wen& Kao, Chih-Chin& Cheng, Shih-Ying& Lu, Hui-Chen…[et al.]. 2014. Genetic Polymorphisms of ORAI1 and Chronic Kidney Disease in Taiwanese Population. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-460810
Modern Language Association (MLA)
Hwang, Daw-Yang…[et al.]. Genetic Polymorphisms of ORAI1 and Chronic Kidney Disease in Taiwanese Population. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-460810
American Medical Association (AMA)
Hwang, Daw-Yang& Chien, Shu-Chen& Hsu, Yu-Wen& Kao, Chih-Chin& Cheng, Shih-Ying& Lu, Hui-Chen…[et al.]. Genetic Polymorphisms of ORAI1 and Chronic Kidney Disease in Taiwanese Population. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-460810
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460810