A Transgenic Mouse Model for Studying the Role of the Parathyroid Hormone-Related Protein System in Renal Injury
Joint Authors
Bover, Jordi
Arribas, Ignacio
Esbrit, Pedro
Ortega, Arantxa
Bosch, Ricardo J.
Izquierdo, Adriana
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Parathyroid hormone- (PTH-) related protein (PTHrP) and its receptor, the PTH1 receptor (PTH1R), are widely expressed in the kidney, where PTHrP exerts a modulatory action on renal function.
PTHrP is known to be upregulated in several experimental nephropathies such as acute renal failure (ARF), obstructive nephropathy (ON) as well as diabetic nephropathy (DN).
In this paper, we will discuss the functional consequences of chronic PTHrP overexpression in the damaged kidney using a transgenic mouse strain overexpressing PTHrP in the renal proximal tubule.
In both ARF and ON, PTHrP displays proinflammatory and profibrogenic actions including the induction of epithelia to mesenquima transition.
Moreover, PTHrP participates in the mechanisms of renal hypertrophy as well as proteinuria in experimental DN.
Angiotensin II (Ang II), a critical factor in the progression of renal injury, appears to be, at least in part, responsible for endogenous PTHrP upregulation in these pathophysiological settings.
These findings provide novel insights into the well-known protective effects of Ang II antagonists in renal diseases, paving the way for new therapeutic approaches.
American Psychological Association (APA)
Bosch, Ricardo J.& Ortega, Arantxa& Izquierdo, Adriana& Arribas, Ignacio& Bover, Jordi& Esbrit, Pedro. 2010. A Transgenic Mouse Model for Studying the Role of the Parathyroid Hormone-Related Protein System in Renal Injury. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-460813
Modern Language Association (MLA)
Bosch, Ricardo J.…[et al.]. A Transgenic Mouse Model for Studying the Role of the Parathyroid Hormone-Related Protein System in Renal Injury. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-460813
American Medical Association (AMA)
Bosch, Ricardo J.& Ortega, Arantxa& Izquierdo, Adriana& Arribas, Ignacio& Bover, Jordi& Esbrit, Pedro. A Transgenic Mouse Model for Studying the Role of the Parathyroid Hormone-Related Protein System in Renal Injury. Journal of Biomedicine and Biotechnology. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-460813
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460813