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CD49b, a Major Marker of Regulatory T-Cells Type 1, Predicts the Response to Antiviral Therapy of Recurrent Hepatitis C after Liver Transplantation
Joint Authors
Nadira, Delhem
Vivian, Viallon
Gautier, Goormachtigh
Laurissa, Ouaguia
Khaldoun, Ghazal
Lynda, Aoudjehane
Fabien, Stenard
Olivier, Morales
Filomena, Conti
Yvon, Calmus
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The TRANSPEG study was a prospective study to assess the efficacy of antiviral therapy in patients with a recurrent hepatitis C virus (HCV) after liver transplantation.
The influence of regulatory T-cells (Tregs) on the response to antiviral therapy was analyzed.
Patients were considered as a function of their sustained virological response (SVR) at 18 months after treatment initiation.
A transcriptomic analysis was performed to assess Treg markers (Tr1 and FoxP3+) in serum, PBMC, and liver biopsies.
100 patients had been included in the TRANSPEG study.
Data from 27 of these patients were available.
The results showed that the expression of CD49b (a predominant marker of Tr1) before the introduction of antiviral therapy was significantly associated with SVR.
Responders displayed lower serum levels of CD49b than nonresponders (P<0.02).
These findings were confirmed in PBMC and liver biopsies even if in a nonsignificant manner for the limited number of samples.
The assessment of CD49b levels is thus predictive of the response to antiviral therapy.
This data suggests that CD49b may be a marker of the failure of the immune response and antiviral therapy during HCV recurrence.
The assessment of CD49b could help to select patients who require earlier and more intensive antiviral therapy.
American Psychological Association (APA)
Fabien, Stenard& Olivier, Morales& Khaldoun, Ghazal& Vivian, Viallon& Lynda, Aoudjehane& Laurissa, Ouaguia…[et al.]. 2014. CD49b, a Major Marker of Regulatory T-Cells Type 1, Predicts the Response to Antiviral Therapy of Recurrent Hepatitis C after Liver Transplantation. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-460814
Modern Language Association (MLA)
Fabien, Stenard…[et al.]. CD49b, a Major Marker of Regulatory T-Cells Type 1, Predicts the Response to Antiviral Therapy of Recurrent Hepatitis C after Liver Transplantation. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-460814
American Medical Association (AMA)
Fabien, Stenard& Olivier, Morales& Khaldoun, Ghazal& Vivian, Viallon& Lynda, Aoudjehane& Laurissa, Ouaguia…[et al.]. CD49b, a Major Marker of Regulatory T-Cells Type 1, Predicts the Response to Antiviral Therapy of Recurrent Hepatitis C after Liver Transplantation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-460814
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460814