Secondary Glioblastoma Multiforme in a Child with Disseminated Juvenile Pilocytic Astrocytoma
Joint Authors
Amene, C. S.
Crawford, John Ross
Yeh-Nayre, L. A.
Source
Case Reports in Oncological Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-19
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Secondary glioblastoma multiforme (sGBM) can occur after a long latency period following radiation treatment of various diseases including brain tumors, leukemia, and more benign disorders like tinea capitis.
Outcomes of radiation-induced sGBM remain poor in both children and adults.
We report a case of a 16-year-old girl with a history of disseminated juvenile pilocytic astrocytoma treated with chemotherapy and craniospinal radiation 9 years prior who developed sGBM in the absence of a tumor predisposition syndrome.
She presented with a several-week history of headaches and no acute findings on computed tomography compared to baseline neuroimaging 3 months prior.
Repeat computed tomography performed just 3 weeks later for worsening headaches revealed a new large posterior fossa tumor where pathology confirmed the diagnosis of sGBM.
In spite of maximal surgical resection, reirradiation, and adjuvant chemotherapy, she died 1 year postdiagnosis.
Our case highlights the potential late effects of high-dose cranial radiation, how symptomatology may precede neuroimaging findings, and the rapid formation of sGBM that mirrors that of de novo Glioblastoma Multiforme.
American Psychological Association (APA)
Amene, C. S.& Yeh-Nayre, L. A.& Crawford, John Ross. 2012. Secondary Glioblastoma Multiforme in a Child with Disseminated Juvenile Pilocytic Astrocytoma. Case Reports in Oncological Medicine،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-460816
Modern Language Association (MLA)
Amene, C. S.…[et al.]. Secondary Glioblastoma Multiforme in a Child with Disseminated Juvenile Pilocytic Astrocytoma. Case Reports in Oncological Medicine No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-460816
American Medical Association (AMA)
Amene, C. S.& Yeh-Nayre, L. A.& Crawford, John Ross. Secondary Glioblastoma Multiforme in a Child with Disseminated Juvenile Pilocytic Astrocytoma. Case Reports in Oncological Medicine. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-460816
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460816