A Systematic Analysis of miRNA-mRNA Paired Variations Reveals Widespread miRNA Misregulation in Breast Cancer
Joint Authors
Zhang, Qingyuan
Zhong, Lei
Yan, Zhaoqi
Jin, Nana
Wu, Deng
Zhu, Kuixi
Zhang, Jianguo
Guo, Baoliang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
MicroRNAs (miRNAs) are a class of small noncoding RNAs that can regulate gene expression by binding to target mRNAs and induce translation repression or RNA degradation.
There have been many studies indicating that both miRNAs and mRNAs display aberrant expression in breast cancer.
Previously, most researches into the molecular mechanism of breast cancer examined miRNA expression patterns and mRNA expression patterns separately.
In this study, we systematically analysed miRNA-mRNA paired variations (MMPVs), which are miRNA-mRNA pairs whose pattern of regulation can vary in association with biopathological features, such as the oestrogen receptor (ER), TP53 and human epidermal growth factor receptor 2 (HER2) genes, survival time, and breast cancer subtypes.
We demonstrated that the existence of MMPVs is general and widespread but that there is a general unbalance in the distribution of MMPVs among the different biopathological features.
Furthermore, based on studying MMPVs that are related to multiple biopathological features, we propose a potential crosstalk mechanism between ER and HER2.
American Psychological Association (APA)
Zhong, Lei& Zhu, Kuixi& Jin, Nana& Wu, Deng& Zhang, Jianguo& Guo, Baoliang…[et al.]. 2014. A Systematic Analysis of miRNA-mRNA Paired Variations Reveals Widespread miRNA Misregulation in Breast Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-460847
Modern Language Association (MLA)
Zhong, Lei…[et al.]. A Systematic Analysis of miRNA-mRNA Paired Variations Reveals Widespread miRNA Misregulation in Breast Cancer. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-460847
American Medical Association (AMA)
Zhong, Lei& Zhu, Kuixi& Jin, Nana& Wu, Deng& Zhang, Jianguo& Guo, Baoliang…[et al.]. A Systematic Analysis of miRNA-mRNA Paired Variations Reveals Widespread miRNA Misregulation in Breast Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-460847
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460847