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Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism
Joint Authors
Sisson, Joseph H.
Pavlik, Jacqueline A.
Sarna, Pawanjit S.
Murphy, Peter J.
Wyatt, Todd A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Vest chest physiotherapy (VCPT) enhances airway clearance in cystic fibrosis (CF) by an unknown mechanism.
Because cilia are sensitive to nitric oxide (NO), we hypothesized that VCPT enhances clearance by changing NO metabolism.
Methods.
Both normal subjects and stable CF subjects had pre- and post-VCPT airway clearance assessed using nasal saccharin transit time (NSTT) followed by a collection of exhaled breath condensate (EBC) analyzed for NO metabolites (NOx).
Results.
VCPT shorted NSTT by 35% in normal and stable CF subjects with no difference observed between the groups.
EBC NOx concentrations decreased 68% in control subjects after VCPT (before = 115 ± 32 μM versus after = 37 ± 17 μM; P<0.002).
CF subjects had a trend toward lower EBC NOx.
Conclusion.
We found an association between VCPT-stimulated clearance and exhaled NOx levels in human subjects.
We speculate that VCPT stimulates clearance via increased NO metabolism.
American Psychological Association (APA)
Sisson, Joseph H.& Wyatt, Todd A.& Pavlik, Jacqueline A.& Sarna, Pawanjit S.& Murphy, Peter J.. 2013. Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism. Pulmonary Medicine،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-460856
Modern Language Association (MLA)
Sisson, Joseph H.…[et al.]. Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism. Pulmonary Medicine No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-460856
American Medical Association (AMA)
Sisson, Joseph H.& Wyatt, Todd A.& Pavlik, Jacqueline A.& Sarna, Pawanjit S.& Murphy, Peter J.. Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism. Pulmonary Medicine. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-460856
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460856