Obesity as a Major Risk Factor for Cancer
Joint Authors
De Pergola, Giovanni
Silvestris, Francesco
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The number of cancer cases caused by being obese is estimated to be 20% with the increased risk of malignancies being influenced by diet, weight change, and body fat distribution together with physical activity.
Reports from the International Agency for Research into Cancer and the World Cancer Research Fund (WCRF) have shown that the strongest evidence exists for an association of obesity with the following cancer types: endometrial, esophageal adenocarcinoma, colorectal, postmenopausal breast, prostate, and renal, whereas the less common malignancies are leukemia, non-Hodgkin’s lymphoma, multiple myeloma, malignant melanoma, and thyroid tumours.
To be able to develop novel methods in prevention and treatment, we first must understand the underlying processes which link cancer to obesity.
Four main systems have been identified as potential producers of cancer in obesity: insulin, insulin-like growth factor-I, sex steroids, and adipokines.
Various novel candidate mechanisms have been proposed: chronic inflammation, oxidative stress, crosstalk between tumour cells and surrounding adipocytes, migrating adipose stromal cells, obesity-induced hypoxia, shared genetic susceptibility, and the functional defeat of immune function.
Herein, we review the major pathogenic links between obesity and susceptibility to cancer.
American Psychological Association (APA)
De Pergola, Giovanni& Silvestris, Francesco. 2013. Obesity as a Major Risk Factor for Cancer. Journal of Obesity،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-460881
Modern Language Association (MLA)
De Pergola, Giovanni& Silvestris, Francesco. Obesity as a Major Risk Factor for Cancer. Journal of Obesity No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-460881
American Medical Association (AMA)
De Pergola, Giovanni& Silvestris, Francesco. Obesity as a Major Risk Factor for Cancer. Journal of Obesity. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-460881
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460881