Rosiglitazone Restores Endothelial Dysfunction in a Rat Model of Metabolic Syndrome through PPARγ- and PPARδ-Dependent Phosphorylation of Akt and eNOS
Joint Authors
Ni, Yinxing
Zhao, Zhigang
Liu, Daoyan
Cao, Tingbing
Zhu, Zhiming
Yan, Zhencheng
Sun, Jing
Chen, Jing
Luo, Zhidan
Wang, Peijian
Yu, Hao
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Vascular endothelial dysfunction has been demonstrated in metabolic syndrome (MS).
Chronic administration of rosiglitazone ameliorates endothelial dysfunction through PPARγ-mediated metabolic improvements.
Recently, studies suggested that single dose of rosiglitazone also has direct vascular effects, but the mechanisms remain uncertain.
Here we established a diet-induced rat model of MS.
The impaired vasorelaxation in MS rats was improved by incubating arteries with rosiglitazone for one hour.
Importantly, this effect was blocked by either inhibition of PPARγ or PPARδ.
In cultured endothelial cells, acute treatment with rosiglitazone increased the phosphorylation of Akt and eNOS and the production of NO.
These effects were also abolished by inhibition of PPARγ, PPARδ, or PI3K.
In conclusion, rosiglitazone improved endothelial function through both PPARγ- and PPARδ-mediated phosphorylation of Akt and eNOS, which might help to reconsider the complex effects and clinical applications of rosiglitazone.
American Psychological Association (APA)
Zhao, Zhigang& Luo, Zhidan& Wang, Peijian& Sun, Jing& Yu, Hao& Cao, Tingbing…[et al.]. 2011. Rosiglitazone Restores Endothelial Dysfunction in a Rat Model of Metabolic Syndrome through PPARγ- and PPARδ-Dependent Phosphorylation of Akt and eNOS. PPAR Research،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-460893
Modern Language Association (MLA)
Zhao, Zhigang…[et al.]. Rosiglitazone Restores Endothelial Dysfunction in a Rat Model of Metabolic Syndrome through PPARγ- and PPARδ-Dependent Phosphorylation of Akt and eNOS. PPAR Research No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-460893
American Medical Association (AMA)
Zhao, Zhigang& Luo, Zhidan& Wang, Peijian& Sun, Jing& Yu, Hao& Cao, Tingbing…[et al.]. Rosiglitazone Restores Endothelial Dysfunction in a Rat Model of Metabolic Syndrome through PPARγ- and PPARδ-Dependent Phosphorylation of Akt and eNOS. PPAR Research. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-460893
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460893