An Experimental Novel Study : Angelica sinensis Prevents Epidural Fibrosis in Laminectomy Rats via Downregulation of Hydroxyproline, IL-6, and TGF-β1
Joint Authors
Liu, Chang
Zhou, Hengxing
Kong, Xiaohong
Sharma, Hari S.
Su, Yanhua
Feng, Shiqing
Zhang, Chao
Zhao, Xuechao
Zhou, Xianhu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
With laminectomy being widely accepted as the treatment for lumbar disorders, epidural fibrosis (EF) is a common complication for both the patients and the surgeons alike.
Currently, EF is thought to cause recurrent postoperative pain after laminectomy or after discectomy.
Angelica sinensis is a traditional Chinese medicine which has shown anti-inflammatory, antifibrotic, and antiproliferative properties.
The object of this study was to investigate the effects of Angelica sinensis on the prevention of post-laminectomy EF formation in a rat model.
A controlled double-blinded study was conducted in sixty healthy adult Wistar rats that underwent laminectomy at the L1-L2 levels.
They were divided randomly into 3 groups according to the treatment method, with 20 in each group: (1) Angelica sinensis treatment group, (2) saline treatment group, and (3) sham group (laminectomy without treatment).
All rats were euthanized humanely 4 weeks after laminectomy.
The hydroxyproline content, Rydell score, vimentin cells density, fibroblasts density, inflammatory cells density, and inflammatory factors expressions all suggested better results in Angelica sinensis group than the other two groups.
Topical application of Angelica sinensis could inhibit fibroblasts proliferation and TGF-β1 and IL-6 expressions and prevent epidural scar adhesion in postlaminectomy rat model.
American Psychological Association (APA)
Zhang, Chao& Kong, Xiaohong& Zhou, Hengxing& Liu, Chang& Zhao, Xuechao& Zhou, Xianhu…[et al.]. 2013. An Experimental Novel Study : Angelica sinensis Prevents Epidural Fibrosis in Laminectomy Rats via Downregulation of Hydroxyproline, IL-6, and TGF-β1. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-460910
Modern Language Association (MLA)
Zhang, Chao…[et al.]. An Experimental Novel Study : Angelica sinensis Prevents Epidural Fibrosis in Laminectomy Rats via Downregulation of Hydroxyproline, IL-6, and TGF-β1. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-460910
American Medical Association (AMA)
Zhang, Chao& Kong, Xiaohong& Zhou, Hengxing& Liu, Chang& Zhao, Xuechao& Zhou, Xianhu…[et al.]. An Experimental Novel Study : Angelica sinensis Prevents Epidural Fibrosis in Laminectomy Rats via Downregulation of Hydroxyproline, IL-6, and TGF-β1. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-460910
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460910