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Chest Radiographs for Pediatric TB Diagnosis : Interrater Agreement and Utility
Joint Authors
Nyokabi, J.
Kaguthi, G.
Nduba, V.
Borgdorff, M.
Gie, R.
Onchiri, F.
Source
Interdisciplinary Perspectives on Infectious Diseases
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The chest radiograph (CXR) is considered a key diagnostic tool for pediatric tuberculosis (TB) in clinical management and endpoint determination in TB vaccine trials.
We set out to compare interrater agreement for TB diagnosis in western Kenya.
A pediatric pulmonologist and radiologist (experts), a medical officer (M.O), and four clinical officers (C.Os) with basic training in pediatric CXR reading blindly assessed CXRs of infants who were TB suspects in a cohort study.
C.Os had access to clinical findings for patient management.
Weighted kappa scores summarized interrater agreement on lymphadenopathy and abnormalities consistent with TB.
Sensitivity and specificity of raters were determined using microbiologically confirmed TB as the gold standard (n=8).
A total of 691 radiographs were reviewed.
Agreement on abnormalities consistent with TB was poor; k=0.14 (95% CI: 0.10–0.18) and on lymphadenopathy moderate k=0.26 (95% CI: 0.18–0.36).
M.O [75% (95% CI: 34.9%–96.8%)] and C.Os [63% (95% CI: 24.5%–91.5%)] had high sensitivity for culture confirmed TB.
TB vaccine trials utilizing expert agreement on CXR as a nonmicrobiologically confirmed endpoint will have reduced specificity and will underestimate vaccine efficacy.
C.Os detected many of the bacteriologically confirmed cases; however, this must be interpreted cautiously as they were unblinded to clinical features.
American Psychological Association (APA)
Kaguthi, G.& Nduba, V.& Nyokabi, J.& Onchiri, F.& Gie, R.& Borgdorff, M.. 2014. Chest Radiographs for Pediatric TB Diagnosis : Interrater Agreement and Utility. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-460914
Modern Language Association (MLA)
Kaguthi, G.…[et al.]. Chest Radiographs for Pediatric TB Diagnosis : Interrater Agreement and Utility. Interdisciplinary Perspectives on Infectious Diseases No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-460914
American Medical Association (AMA)
Kaguthi, G.& Nduba, V.& Nyokabi, J.& Onchiri, F.& Gie, R.& Borgdorff, M.. Chest Radiographs for Pediatric TB Diagnosis : Interrater Agreement and Utility. Interdisciplinary Perspectives on Infectious Diseases. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-460914
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460914