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Mild Cognitive Impairment : Statistical Models of Transition Using Longitudinal Clinical Data
Joint Authors
Abner, Erin L.
Cooper, Gregory E.
Fardo, David W.
Wan, Lijie
Smith, Charles D.
Jicha, Gregory A.
Kryscio, Richard J.
Nelson, Peter T.
Van Eldik, Linda J.
Schmitt, Frederick A.
Mendiondo, Marta S.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Mild cognitive impairment (MCI) refers to the clinical state between normal cognition and probable Alzheimer’s disease (AD), but persons diagnosed with MCI may progress to non-AD forms of dementia, remain MCI until death, or recover to normal cognition.
Risk factors for these various clinical changes, which we term “transitions,” may provide targets for therapeutic interventions.
Therefore, it is useful to develop new approaches to assess risk factors for these transitions.
Markov models have been used to investigate the transient nature of MCI represented by amnestic single-domain and mixed MCI states, where mixed MCI comprised all other MCI subtypes based on cognitive assessments.
The purpose of this study is to expand this risk model by including a clinically determined MCI state as an outcome.
Analyses show that several common risk factors play different roles in affecting transitions to MCI and dementia.
Notably, APOE-4 increases the risk of transition to clinical MCI but does not affect the risk for a final transition to dementia, and baseline hypertension decreases the risk of transition to dementia from clinical MCI.
American Psychological Association (APA)
Abner, Erin L.& Kryscio, Richard J.& Cooper, Gregory E.& Fardo, David W.& Jicha, Gregory A.& Mendiondo, Marta S.…[et al.]. 2012. Mild Cognitive Impairment : Statistical Models of Transition Using Longitudinal Clinical Data. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-460927
Modern Language Association (MLA)
Abner, Erin L.…[et al.]. Mild Cognitive Impairment : Statistical Models of Transition Using Longitudinal Clinical Data. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-460927
American Medical Association (AMA)
Abner, Erin L.& Kryscio, Richard J.& Cooper, Gregory E.& Fardo, David W.& Jicha, Gregory A.& Mendiondo, Marta S.…[et al.]. Mild Cognitive Impairment : Statistical Models of Transition Using Longitudinal Clinical Data. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-460927
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460927