![](/images/graphics-bg.png)
Spinal Serotonergic and Opioid Receptors Are Involved in Electroacupuncture-Induced Antinociception at Different Frequencies on ZuSanLi (ST 36) Acupoint
Joint Authors
Kuo, Chi-Chung
Su, Hong-Lin
Lin, Jaung Geng
Tsai, Huei-Yann
Chen, Yuh-Fung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The present study was conducted to evaluate the effect of electroacupuncture-(EAc-) induced antinociception (EAA) at different currents and frequencies in rat spinal cord.
We found that naloxone (0.05 μg i.t.) blocked EAA at different frequencies.
Naltrindole (0.05 μg i.t.) blocked EAA on the 7th day after EAc of 100 Hz.
5,7-Dihydroxytryptamine (100 μg i.t.) significantly inhibited EAA at different frequencies on the 7th day after EAc.
Pindobind (0.5 μg i.t.), a 5-HT1A antagonist, notably attenuated EAA at different frequencies.
Ketanserin (0.5 μg i.t.), inhibited EEA at a lower frequency (<10 Hz) than at a higher frequency (100 Hz).
LY-278584 (0.5 μg i.t.) significantly inhibited EAA at a higher frequency (100 Hz) on the 7th day after EAc.
The direction of effect of 8-OH-DPAT, on EAA was dependent on dosage.
It had an inhibitory effect at a low dose (0.5 μg i.t.) and a high frequency (100 Hz) but enhanced EAA at a higher dose at lower frequencies (<10 Hz).
DOI (10 μg, i.t.), did not affect EAA.
These data indicate that the mechanism of EAA involves opioid receptors, and the serotonergic system, particularly, μ-, δ-opioid and 5-HT1A, 5-HT3 receptors and it is also dependent on the EAc frequency.
American Psychological Association (APA)
Kuo, Chi-Chung& Tsai, Huei-Yann& Lin, Jaung Geng& Su, Hong-Lin& Chen, Yuh-Fung. 2013. Spinal Serotonergic and Opioid Receptors Are Involved in Electroacupuncture-Induced Antinociception at Different Frequencies on ZuSanLi (ST 36) Acupoint. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-460936
Modern Language Association (MLA)
Kuo, Chi-Chung…[et al.]. Spinal Serotonergic and Opioid Receptors Are Involved in Electroacupuncture-Induced Antinociception at Different Frequencies on ZuSanLi (ST 36) Acupoint. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-460936
American Medical Association (AMA)
Kuo, Chi-Chung& Tsai, Huei-Yann& Lin, Jaung Geng& Su, Hong-Lin& Chen, Yuh-Fung. Spinal Serotonergic and Opioid Receptors Are Involved in Electroacupuncture-Induced Antinociception at Different Frequencies on ZuSanLi (ST 36) Acupoint. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-460936
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460936