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Influence of Methylenetetrahydrofolate Reductase C677T, A1298C, and G80A Polymorphisms on the Survival of Pediatric Patients with Acute Lymphoblastic Leukemia
Joint Authors
Seabra Silva, Rafaela Maria
de Lima, Elker Lene Santos
de Deus, Dayse Maria Vasconcelos
Cartaxo Muniz, Maria Tereza
Leite, Edinalva Pereira
Source
Leukemia Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Mechanical Engineering
Medicine
Abstract EN
The influence of genic polymorphisms involved in metabolism of chemotherapeutic agents as the methotrexate (MTX) has been studied mainly in acute lymphoblastic leukemia (ALL) of childhood.
Advances in treatment may be attributed to identification of prognostic factors added to chemotherapy protocol.
The aim of this study was to analyze the association of the C677T, A1298C, and G80A polymorphisms on MTHFR gene and on the overall survival of pediatric patients (n=126) with lymphoblastic leukemia treated with MTX according to the Brazilian protocol in 187 months.
The C677T and G80A polymorphisms were genotyped by PCR-RFLP and A1298C polymorphism by allele-specific PCR.
We observed that ALL patients presented rate (dead/alive) of 0.36 for the 677CC genotype, corresponding also to lower overall survival (P=0.0013); on the other hand, the 677TT genotype showed a better survival (98%).
Thus, we believe that patients with 80AA genotype presented a small reduction in MTX plasma level, suggesting that ALL children, carrying the 80AA genotype, showed a high toxicity to MTX (P<0.0001).
American Psychological Association (APA)
de Deus, Dayse Maria Vasconcelos& de Lima, Elker Lene Santos& Seabra Silva, Rafaela Maria& Leite, Edinalva Pereira& Cartaxo Muniz, Maria Tereza. 2012. Influence of Methylenetetrahydrofolate Reductase C677T, A1298C, and G80A Polymorphisms on the Survival of Pediatric Patients with Acute Lymphoblastic Leukemia. Leukemia Research and Treatment،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-460943
Modern Language Association (MLA)
de Deus, Dayse Maria Vasconcelos…[et al.]. Influence of Methylenetetrahydrofolate Reductase C677T, A1298C, and G80A Polymorphisms on the Survival of Pediatric Patients with Acute Lymphoblastic Leukemia. Leukemia Research and Treatment No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-460943
American Medical Association (AMA)
de Deus, Dayse Maria Vasconcelos& de Lima, Elker Lene Santos& Seabra Silva, Rafaela Maria& Leite, Edinalva Pereira& Cartaxo Muniz, Maria Tereza. Influence of Methylenetetrahydrofolate Reductase C677T, A1298C, and G80A Polymorphisms on the Survival of Pediatric Patients with Acute Lymphoblastic Leukemia. Leukemia Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-460943
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460943