![](/images/graphics-bg.png)
Reduction of Experimental Cerebral Malaria and Its Related Proinflammatory Responses by the Novel Liposome-Based β-Methasone Nanodrug
Joint Authors
Golenser, Jacob
Waknine-Grinberg, Judith H.
Guo, Jintao
Mitchell, Andrew J.
Barenholz, Yechezkel
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cerebral malaria (CM) is a severe complication of and a leading cause of death due to Plasmodium falciparum infection.
CM is likely the result of interrelated events, including mechanical obstruction due to parasite sequestration in the microvasculature, and upregulation of Th1 immune responses.
In parallel, blood-brain-barrier (BBB) breakdown and damage or death of microglia, astrocytes, and neurons occurs.
We found that a novel formulation of a liposome-encapsulated glucocorticosteroid, β-methasone hemisuccinate (nSSL-BMS), prevents experimental cerebral malaria (ECM) in a murine model and creates a survival time-window, enabling administration of an antiplasmodial drug before severe anemia develops.
nSSL-BMS treatment leads to lower levels of cerebral inflammation, expressed by altered levels of corresponding cytokines and chemokines.
The results indicate the role of integrated immune responses in ECM induction and show that the new steroidal nanodrug nSSL-BMS reverses the balance between the Th1 and Th2 responses in malaria-infected mice so that the proinflammatory processes leading to ECM are prevented.
Overall, because of the immunopathological nature of CM, combined immunomodulator/antiplasmodial treatment should be considered for prevention/treatment of human CM and long-term cognitive damage.
American Psychological Association (APA)
Guo, Jintao& Waknine-Grinberg, Judith H.& Mitchell, Andrew J.& Barenholz, Yechezkel& Golenser, Jacob. 2014. Reduction of Experimental Cerebral Malaria and Its Related Proinflammatory Responses by the Novel Liposome-Based β-Methasone Nanodrug. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-460965
Modern Language Association (MLA)
Guo, Jintao…[et al.]. Reduction of Experimental Cerebral Malaria and Its Related Proinflammatory Responses by the Novel Liposome-Based β-Methasone Nanodrug. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-460965
American Medical Association (AMA)
Guo, Jintao& Waknine-Grinberg, Judith H.& Mitchell, Andrew J.& Barenholz, Yechezkel& Golenser, Jacob. Reduction of Experimental Cerebral Malaria and Its Related Proinflammatory Responses by the Novel Liposome-Based β-Methasone Nanodrug. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-460965
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460965