In Vitro Systems for the Study of Hepatitis C Virus Infection
Joint Authors
Wilson, Garrick K.
Stamataki, Zania
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The study of a virus is made possible by the availability of culture systems in which the viral lifecycle can be realized.
Such systems support robust virus entry, replication, assembly, and secretion of nascent virions.
Furthermore, culture models provide a platform in which therapeutic interventions can be devised or monitored.
Hepatitis C virus (HCV) has a restricted tropism to human and chimpanzees; thus investigations of HCV biology have been hindered for many years due to a lack of small animal models.
Nevertheless, significant efforts have been directed at developing cell culture models to elucidate the viral lifecycle in vitro.
HCV primarily infects liver parenchymal cells commonly known as hepatocytes.
The liver is a highly specialized and complex organ and the development of in vitro systems that reflects this complexity has proven difficult.
Consequently, host cell receptor molecules that potentiate HCV infection were identified over a decade after the virus was discovered.
A summary of the various HCV in vitro culture models, their advantages, and disadvantages are described.
American Psychological Association (APA)
Wilson, Garrick K.& Stamataki, Zania. 2012. In Vitro Systems for the Study of Hepatitis C Virus Infection. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-460976
Modern Language Association (MLA)
Wilson, Garrick K.& Stamataki, Zania. In Vitro Systems for the Study of Hepatitis C Virus Infection. International Journal of Hepatology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-460976
American Medical Association (AMA)
Wilson, Garrick K.& Stamataki, Zania. In Vitro Systems for the Study of Hepatitis C Virus Infection. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-460976
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460976