Glutamate-Mediated Primary Somatosensory Cortex Excitability Correlated with Circulating Copper and Ceruloplasmin
Joint Authors
Giovanni, Assenza
Tecchio, Franca
Squitti, Rosanna
Zappasodi, Filippo
Salustri, Carlo
Mariani, Stefania
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To verify whether markers of metal homeostasis are related to a magnetoencephalographic index representative of glutamate-mediated excitability of the primary somatosensory cortex.
The index is identified as the source strength of the earliest component (M20) of the somatosensory magnetic fields (SEFs) evoked by right median nerve stimulation at wrist.
Method.
Thirty healthy right-handed subjects (51±22 years) were enrolled in the study.
A source reconstruction algorithm was applied to assess the amount of synchronously activated neurons subtending the M20 and the following SEF component (M30), which is generated by two independent contributions of gabaergic and glutamatergic transmission.
Serum copper, ceruloplasmin, iron, transferrin, transferrin saturation, and zinc levels were measured.
Results.
Total copper and ceruloplasmin negatively correlated with the M20 source strength.
Conclusion.
This pilot study suggests that higher level of body copper reserve, as marked by ceruloplasmin variations, parallels lower cortical glutamatergic responsiveness.
American Psychological Association (APA)
Tecchio, Franca& Giovanni, Assenza& Zappasodi, Filippo& Mariani, Stefania& Salustri, Carlo& Squitti, Rosanna. 2011. Glutamate-Mediated Primary Somatosensory Cortex Excitability Correlated with Circulating Copper and Ceruloplasmin. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-460977
Modern Language Association (MLA)
Tecchio, Franca…[et al.]. Glutamate-Mediated Primary Somatosensory Cortex Excitability Correlated with Circulating Copper and Ceruloplasmin. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-460977
American Medical Association (AMA)
Tecchio, Franca& Giovanni, Assenza& Zappasodi, Filippo& Mariani, Stefania& Salustri, Carlo& Squitti, Rosanna. Glutamate-Mediated Primary Somatosensory Cortex Excitability Correlated with Circulating Copper and Ceruloplasmin. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-460977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460977