Transforming Growth Factor-β1 Gene Polymorphism (T29C) in Egyptian Patients with Hepatitis B Virus Infection : A Preliminary Study
Joint Authors
Talaat, Roba M.
Khamiss, Omaima A.
El-Shenawy, Soha Z.
Dondeti, Mahmoud F.
Source
Hepatitis Research and Treatment
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The interindividual variations in the capacity of transforming growth factor-β1 (TGF-β1) production have been ascribed to genetic polymorphisms in TGF-β1 gene.
As pathogenesis of HBV has a genetic background, this preliminary study was designed to assess the impact of TGF-β1 (T29C) on the susceptibility of Egyptians to HBV infection.
Genotyping was performed using single stranded polymorphism-polymerase chain reaction (SSP-PCR) in 65 Egyptian hepatitis B patients and 50 healthy controls.
TGF-β1 plasma levels were measured using Enzyme-linked immunosorbent assay (ELISA).
The frequency of CC genotype was significantly higher (P<0.05) in HBV patients compared to controls.
On the contrary, TC genotype did not show significant difference in both groups.
TT genotype was significantly higher (P<0.01) in controls than HBV patients.
Our current preliminary data revealed that the frequency of the genotypes in the controls were within Hardy-Weinberg equilibrium (HWE) while the patients group was out of HWE (P<0.01).
TGF-β1 was significantly (r=-0.684; P<0.001) deceased in the sera of patients as compared to normal subjects.
Depending on our preliminary work, CC genotype may act as a host genetic factor in the susceptibility to HBV infection in Egyptians.
Taken together, the current data pointed to the importance of polymorphism of TGF-β1 gene (T29C) in HBV infection.
American Psychological Association (APA)
Talaat, Roba M.& Dondeti, Mahmoud F.& El-Shenawy, Soha Z.& Khamiss, Omaima A.. 2013. Transforming Growth Factor-β1 Gene Polymorphism (T29C) in Egyptian Patients with Hepatitis B Virus Infection : A Preliminary Study. Hepatitis Research and Treatment،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-461027
Modern Language Association (MLA)
Talaat, Roba M.…[et al.]. Transforming Growth Factor-β1 Gene Polymorphism (T29C) in Egyptian Patients with Hepatitis B Virus Infection : A Preliminary Study. Hepatitis Research and Treatment No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-461027
American Medical Association (AMA)
Talaat, Roba M.& Dondeti, Mahmoud F.& El-Shenawy, Soha Z.& Khamiss, Omaima A.. Transforming Growth Factor-β1 Gene Polymorphism (T29C) in Egyptian Patients with Hepatitis B Virus Infection : A Preliminary Study. Hepatitis Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-461027
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461027