PPARαγ-Independent Effects of PPARαγ Ligands on Cysteinyl Leukotriene Production in Mast Cells
Author
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-11-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptor (PPAR) α ligands (Wy-14,643, and fenofibrate) and PPARγ ligands (troglitazone and ciglitazone) inhibit antigen-induced cysteinyl leukotriene production in immunoglobulin E-treated mast cells.
The inhibitory effect of these ligands on cysteinyl leukotriene production is quite strong and is almost equivalent to that of the anti-asthma compound zileuton.
To develop new aspects for anti-asthma drugs the pharmacological target of these compounds should be clarified.
Experiments with bone-marrow-derived mast cells from PPARα knockout mice and pharmacological inhibitors of PPARγ suggest that the inhibitory effects of these ligands are independent of PPARs α and γ.
The mechanisms of the PPAR-independent inhibition by these agents on cysteinyl leukotriene production are discussed in this review.
American Psychological Association (APA)
Yamashita, Masamichi. 2008. PPARαγ-Independent Effects of PPARαγ Ligands on Cysteinyl Leukotriene Production in Mast Cells. PPAR Research،Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-461044
Modern Language Association (MLA)
Yamashita, Masamichi. PPARαγ-Independent Effects of PPARαγ Ligands on Cysteinyl Leukotriene Production in Mast Cells. PPAR Research No. 2008 (2008), pp.1-6.
https://search.emarefa.net/detail/BIM-461044
American Medical Association (AMA)
Yamashita, Masamichi. PPARαγ-Independent Effects of PPARαγ Ligands on Cysteinyl Leukotriene Production in Mast Cells. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-461044
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461044
