Signaling Required for Blood Vessel Maintenance : Molecular Basis and Pathological Manifestations
Author
Source
International Journal of Vascular Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-06
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
As our understanding of molecular mechanisms leading to vascular formation increases, vessel maintenance including stabilization of new vessels and prevention of vessel regression began to be considered as an active process that requires specific cellular signaling.
While signaling pathways such as VEGF, FGF, and angiopoietin-Tie2 are important for endothelial cell survival and junction stabilization, PDGF and TGF-β signaling modify mural cell (vascular smooth muscle cells and pericytes) functions, thus they fortify vessel integrity.
Breakdown of these signaling systems results in pathological hyperpermeability and/or genetic vascular abnormalities such as vascular malformations, ultimately progressing to hemorrhage and edema.
Hence, blood vessel maintenance is fundamental to controlling vascular homeostasis and tissue functions.
This paper discusses signaling pathways essential for vascular maintenance and clinical conditions caused by deterioration of vessel integrity.
American Psychological Association (APA)
Murakami, Masahiro. 2011. Signaling Required for Blood Vessel Maintenance : Molecular Basis and Pathological Manifestations. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-461057
Modern Language Association (MLA)
Murakami, Masahiro. Signaling Required for Blood Vessel Maintenance : Molecular Basis and Pathological Manifestations. International Journal of Vascular Medicine No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-461057
American Medical Association (AMA)
Murakami, Masahiro. Signaling Required for Blood Vessel Maintenance : Molecular Basis and Pathological Manifestations. International Journal of Vascular Medicine. 2011. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-461057
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461057